Evidence map›Paper›PMID 25548261›Full record

Trial reportJournal of lipid research2015

CETP genotype and changes in lipid levels in response to weight-loss diet intervention in the POUNDS LOST and DIRECT randomized trials.

Qibin Qi, Ronen Durst, Dan Schwarzfuchs, Eran Leitersdorf, Shoshi Shpitzen, Yanping Li, Hongyu Wu, Catherine M Champagne, Frank B Hu, Meir J Stampfer and 4 more

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of lipid research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Effects of total fat intake on body fatness in adults.The Cochrane database of systematic reviews · 2020
    Pooled it
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  20. Nutrigenetics-personalized nutrition in obesity and cardiovascular diseases.International journal of obesity supplements · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Qibin QiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY; Departments of Nutrition Harvard School of Public Health, Boston, MA.
Ronen DurstCardiology Department Hadassah Hebrew University Medical Center, Jerusalem, Israel; Center for Research, Prevention, and Treatment of Atherosclerosis Internal Medicine Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Dan SchwarzfuchsNuclear Research Center, Dimona, Israel.
Eran LeitersdorfCenter for Research, Prevention, and Treatment of Atherosclerosis Internal Medicine Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Shoshi ShpitzenCenter for Research, Prevention, and Treatment of Atherosclerosis Internal Medicine Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Yanping LiDepartments of Nutrition Harvard School of Public Health, Boston, MA.
Hongyu WuDepartments of Nutrition Harvard School of Public Health, Boston, MA.
Catherine M ChampagnePennington Biomedical Research Center of the Louisiana State University System, Baton Rouge, LA.
Frank B HuDepartments of Nutrition Harvard School of Public Health, Boston, MA; Epidemiology, Harvard School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Meir J StampferDepartments of Nutrition Harvard School of Public Health, Boston, MA; Epidemiology, Harvard School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
George A BrayPennington Biomedical Research Center of the Louisiana State University System, Baton Rouge, LA.
Frank M SacksDepartments of Nutrition Harvard School of Public Health, Boston, MA.
Iris ShaiDepartment of Public Health, Ben Gurion University of the Negev, Beer Sheva, Israel.
Lu QiDepartments of Nutrition Harvard School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. Electronic address: nhlqi@channing.harvard.edu.
Harvard University · USHadassah Medical Center · ILBrigham and Women's Hospital · USBen-Gurion University of the Negev · ILLouisiana State University System · USPennington Biomedical Research Center · US

Funding

Zoledronic Acid in Treatment of Osteoporosis in PostmenoM01RR002635 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI GARBER, JUDY E. · 1985 to 2008
$48.4M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0M
Sleep Duration, Childhood Energy Balance, and Insulin Resistance in AdolescenceU54CA155626 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI HU, FRANK B · 2011 to 2015
$9.6M
Genetic Markers of CHD in Type 2 DiabetesR01HL071981 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI QI, LU · 2003 to 2012
$4.9M
Obesity Genes, Energy Regulation in Response to Weight-Loss DietsR01DK091718 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2012 to 2021
$4.5M
NCI NIH HHS CA155626NCI NIH HHS U54 CA155626NCRR NIH HHS M01 RR002635NCRR NIH HHS RR-02635NHLBI NIH HHS HL071981NHLBI NIH HHS R01 HL071981NIDDK NIH HHS DK091718NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK091718
6 · The paper itself

Abstract

Little is known about whether cholesteryl ester transfer protein (CETP) genetic variation may modify the effect of weight-loss diets varying in fat content on changes in lipid levels. We analyzed the interaction between the CETP variant rs3764261 and dietary interventions on changes in lipid levels among 732 overweight/obese adults from a 2 year randomized weight-loss trial [Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST)], and replicated the findings in 171 overweight/obese adults from an independent 2 year weight-loss trial [Dietary Intervention Randomized Controlled Trial (DIRECT)]. In the POUNDS LOST, participants with the CETP rs3764261 CC genotype on the high-fat diet had larger increases in HDL cholesterol (P = 0.001) and decreases in triglycerides (P = 0.007) than those on the low-fat diet at 6 months, while no significant difference between these two diets was observed among participants carrying other genotypes. The gene-diet interactions on changes in HDL-cholesterol and tri-glyc-erides were replicated in the DIRECT (pooled P for interaction ≤ 0.01). Similar results on trajectory of changes in HDL cholesterol and triglycerides over the 2 year intervention were observed in both trials. Our study provides replicable evidence that individuals with the CETP rs3764261 CC genotype might derive greater effects on raising HDL cholesterol and lowering triglycerides by choosing a low-carbohydrate/high-fat weight-loss diet instead of a low-fat diet.

Indexed as

GenotypeObesityWeight LossAdultAgedCholesterol Ester Transfer ProteinsCholesterol, HDLDietary FatsFemaleFollow-Up StudiesHumansMaleMiddle AgedTriglyceridesCETP protein, humanCholesterol Ester Transfer ProteinsCholesterol, HDLDietary FatsTriglyceridescholesteryl ester transfer proteinDietary Intervention Randomized Controlled Trialgene-diet interactionPreventing Overweight Using Novel Dietary Strategies

Identifiers

PMID25548261
PMCPMC4340318
OpenAlexW2085115033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.