ArticleJournal of immunology (Baltimore, Md. : 1950)2015
Antibody-mediated trapping of helminth larvae requires CD11b and Fcγ receptor I.
Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Immunity to helminths in complex environments: co-infection disrupts effective granuloma formation and parasite clearance.Discovery immunology · 2026Article
- Differential generation of parasite-specific Th2 and T follicular helper cells distinguishes resistant and susceptible mouse strains.Frontiers in immunology · 2026Article
- Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense.Science (New York, N.Y.) · 2025Article
- Vaccination against helminth IL-33 modulators permits immune-mediated parasite ejection.Cell reports · 2025Article
- Larval ascariasis elicits a prominent IgA and IgG1/2 antibody response to adultFrontiers in immunology · 2025Article
- Targeting helminths: The expanding world of type 2 immune effector mechanisms.The Journal of experimental medicine · 2023Review
- Th2-dependent STAT6-regulated genes in intestinal epithelial cells mediate larval trapping during secondary Heligmosomoides polygyrus bakeri infection.PLoS pathogens · 2023Article
- Regulation of immune response against third-stageFrontiers in immunology · 2023Article
- Microbial regulation of intestinal motility provides resistance against helminth infection.Mucosal immunology · 2022Article
- β-Glucan receptors on IL-4 activated macrophages are required for hookworm larvae recognition and trapping.Immunology and cell biology · 2022Article
- A newly identified secreted larval antigen elicits basophil-dependent protective immunity againstFrontiers in immunology · 2022Article
- Trickle infection withFrontiers in immunology · 2022Article
- Transgenic expression of a T cell epitope in Strongyloides ratti reveals that helminth-specific CD4+ T cells constitute both Th2 and Treg populations.PLoS pathogens · 2021Article
- Context-dependent roles of B cells during intestinal helminth infection.PLoS neglected tropical diseases · 2021Review
- Eosinophils and Macrophages within the Th2-Induced Granuloma: Balancing Killing and Healing in a Tight Space.Infection and immunity · 2019Review
- Host-Parasite Interactions Promote Disease Tolerance to Intestinal Helminth Infection.Frontiers in immunology · 2018Review
- Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse.Journal of immunology research · 2018Review
- Epithelial-Cell-Derived Phospholipase ACell host & microbe · 2017Article
- Immune antibodies and helminth products drive CXCR2-dependent macrophage-myofibroblast crosstalk to promote intestinal repair.PLoS pathogens · 2015Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infections with intestinal helminths severely impact on human and veterinary health, particularly through the damage that these large parasites inflict when migrating through host tissues. Host immunity often targets the motility of tissue-migrating helminth larvae, which ideally should be mimicked by anti-helminth vaccines. However, the mechanisms of larval trapping are still poorly defined. We have recently reported an important role for Abs in the rapid trapping of tissue-migrating larvae of the murine parasite Heligmosomoides polygyrus bakeri. Trapping was mediated by macrophages (MΦ) and involved complement, activating FcRs, and Arginase-1 (Arg1) activity. However, the receptors and Ab isotypes responsible for MΦ adherence and Arg1 induction remained unclear. Using an in vitro coculture assay of H. polygyrus bakeri larvae and bone marrow-derived MΦ, we now identify CD11b as the major complement receptor mediating MΦ adherence to the larval surface. However, larval immobilization was largely independent of CD11b and instead required the activating IgG receptor FcγRI (CD64) both in vitro and during challenge H. polygyrus bakeri infection in vivo. FcγRI signaling also contributed to the upregulation of MΦ Arg1 expression in vitro and in vivo. Finally, IgG2a/c was the major IgG subtype from early immune serum bound by FcγRI on the MΦ surface, and purified IgG2c could trigger larval immobilization and Arg1 expression in MΦ in vitro. Our findings reveal a novel role for IgG2a/c-FcγRI-driven MΦ activation in the efficient trapping of tissue-migrating helminth larvae and thus provide important mechanistic insights vital for anti-helminth vaccine development.
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