Evidence map›Paper›PMID 25548108›Full record

ArticleThe international journal of neuropsychopharmacology2014

Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia.

Olga Yu Fedorenko, Anton J M Loonen, Florian Lang, Valentina A Toshchakova, Evgenia G Boyarko, Arkadiy V Semke, Nikolay A Bokhan, Nikolay V Govorin, Lyubomir I Aftanas, Svetlana A Ivanova

Open access · bronzeAbstract readMulticenter Study

PubMed Full text at PMC Publisher

In one paragraph

Article in The international journal of neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it

0cells of the map it votes in

12citing papers in PubMed

1.2field-weighted citation impact, top 24% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 37 citations in OpenAlex.

Polymorphic Variants of Neurotrophic Factor Genes in Affective Disorders: Pilot Study.International journal of molecular sciences · 2025
Article
Association ofGenes · 2021
Article
Genome wide study of tardive dyskinesia in schizophrenia.Translational psychiatry · 2021
Article
Genetic Factors Associated With Tardive Dyskinesia: From Pre-clinical Models to Clinical Studies.Frontiers in pharmacology · 2021
Review
Tardive Dyskinesia in Older Persons Taking Antipsychotics.Neuropsychiatric disease and treatment · 2021
Review
Genetic polymorphisms of PIP5K2A and course of schizophrenia.BMC medical genetics · 2020
Article
Frontiers in genetics · 2020
Article
Opening up new horizons for psychiatric genetics in the Russian Federation: moving toward a national consortium.Molecular psychiatry · 2019
Article
Phosphoinositides: Regulators of Nervous System Function in Health and Disease.Frontiers in molecular neuroscience · 2019
Review
Safety, tolerability, and risks associated with first- and second-generation antipsychotics: a state-of-the-art clinical review.Therapeutics and clinical risk management · 2017
Review
Medication-Induced Tardive Dyskinesia: A Review and Update.Ochsner journal · 2017
Review
Association study of MiRSNPs with schizophrenia, tardive dyskinesia and cognition.Schizophrenia research · 2016
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Olga Yu FedorenkoMental Health Research Institute, SiberianBranch of RAMSc, Tomsk, Siberia, Russian Federation (Drs Fedorenko, Toshchakova, Boyarko, Semke, Bokhan, and Ivanova); National Research Tomsk Polytechnic University, Tomsk, Siberia, Russian Federation (Drs Fedorenko and Ivanova); Department of Pharmacy, University of Groningen, Groningen, The Netherlands (Dr Loonen); Mental Health Institute Westelijk Noord-Brabant, Halsteren, The Netherlands (Dr Loonen); Department of Physiology, University of Tuebingen, Tuebingen, Germany (Dr Lang); Chita State Medical Academy, Chita, Siberia, Russian Federation (Dr Govorin); National Research Tomsk State University, Tomsk, Siberia, Russian Federation (Dr Bokhan); Scientific Research Institute of Physiology and Basic Medicine, Siberian Branch of RAMSc, Novosibirsk, Siberia, Russian Federation (Dr Aftanas).

Anton J M LoonenMental Health Research Institute, SiberianBranch of RAMSc, Tomsk, Siberia, Russian Federation (Drs Fedorenko, Toshchakova, Boyarko, Semke, Bokhan, and Ivanova); National Research Tomsk Polytechnic University, Tomsk, Siberia, Russian Federation (Drs Fedorenko and Ivanova); Department of Pharmacy, University of Groningen, Groningen, The Netherlands (Dr Loonen); Mental Health Institute Westelijk Noord-Brabant, Halsteren, The Netherlands (Dr Loonen); Department of Physiology, University of Tuebingen, Tuebingen, Germany (Dr Lang); Chita State Medical Academy, Chita, Siberia, Russian Federation (Dr Govorin); National Research Tomsk State University, Tomsk, Siberia, Russian Federation (Dr Bokhan); Scientific Research Institute of Physiology and Basic Medicine, Siberian Branch of RAMSc, Novosibirsk, Siberia, Russian Federation (Dr Aftanas). a.j.m.loonen@rug.nl.

Florian LangMental Health Research Institute, SiberianBranch of RAMSc, Tomsk, Siberia, Russian Federation (Drs Fedorenko, Toshchakova, Boyarko, Semke, Bokhan, and Ivanova); National Research Tomsk Polytechnic University, Tomsk, Siberia, Russian Federation (Drs Fedorenko and Ivanova); Department of Pharmacy, University of Groningen, Groningen, The Netherlands (Dr Loonen); Mental Health Institute Westelijk Noord-Brabant, Halsteren, The Netherlands (Dr Loonen); Department of Physiology, University of Tuebingen, Tuebingen, Germany (Dr Lang); Chita State Medical Academy, Chita, Siberia, Russian Federation (Dr Govorin); National Research Tomsk State University, Tomsk, Siberia, Russian Federation (Dr Bokhan); Scientific Research Institute of Physiology and Basic Medicine, Siberian Branch of RAMSc, Novosibirsk, Siberia, Russian Federation (Dr Aftanas).

Valentina A ToshchakovaMental Health Research Institute, SiberianBranch of RAMSc, Tomsk, Siberia, Russian Federation (Drs Fedorenko, Toshchakova, Boyarko, Semke, Bokhan, and Ivanova); National Research Tomsk Polytechnic University, Tomsk, Siberia, Russian Federation (Drs Fedorenko and Ivanova); Department of Pharmacy, University of Groningen, Groningen, The Netherlands (Dr Loonen); Mental Health Institute Westelijk Noord-Brabant, Halsteren, The Netherlands (Dr Loonen); Department of Physiology, University of Tuebingen, Tuebingen, Germany (Dr Lang); Chita State Medical Academy, Chita, Siberia, Russian Federation (Dr Govorin); National Research Tomsk State University, Tomsk, Siberia, Russian Federation (Dr Bokhan); Scientific Research Institute of Physiology and Basic Medicine, Siberian Branch of RAMSc, Novosibirsk, Siberia, Russian Federation (Dr Aftanas).

Evgenia G BoyarkoMental Health Research Institute, SiberianBranch of RAMSc, Tomsk, Siberia, Russian Federation (Drs Fedorenko, Toshchakova, Boyarko, Semke, Bokhan, and Ivanova); National Research Tomsk Polytechnic University, Tomsk, Siberia, Russian Federation (Drs Fedorenko and Ivanova); Department of Pharmacy, University of Groningen, Groningen, The Netherlands (Dr Loonen); Mental Health Institute Westelijk Noord-Brabant, Halsteren, The Netherlands (Dr Loonen); Department of Physiology, University of Tuebingen, Tuebingen, Germany (Dr Lang); Chita State Medical Academy, Chita, Siberia, Russian Federation (Dr Govorin); National Research Tomsk State University, Tomsk, Siberia, Russian Federation (Dr Bokhan); Scientific Research Institute of Physiology and Basic Medicine, Siberian Branch of RAMSc, Novosibirsk, Siberia, Russian Federation (Dr Aftanas).

Arkadiy V SemkeMental Health Research Institute, SiberianBranch of RAMSc, Tomsk, Siberia, Russian Federation (Drs Fedorenko, Toshchakova, Boyarko, Semke, Bokhan, and Ivanova); National Research Tomsk Polytechnic University, Tomsk, Siberia, Russian Federation (Drs Fedorenko and Ivanova); Department of Pharmacy, University of Groningen, Groningen, The Netherlands (Dr Loonen); Mental Health Institute Westelijk Noord-Brabant, Halsteren, The Netherlands (Dr Loonen); Department of Physiology, University of Tuebingen, Tuebingen, Germany (Dr Lang); Chita State Medical Academy, Chita, Siberia, Russian Federation (Dr Govorin); National Research Tomsk State University, Tomsk, Siberia, Russian Federation (Dr Bokhan); Scientific Research Institute of Physiology and Basic Medicine, Siberian Branch of RAMSc, Novosibirsk, Siberia, Russian Federation (Dr Aftanas).

Nikolay A BokhanMental Health Research Institute, SiberianBranch of RAMSc, Tomsk, Siberia, Russian Federation (Drs Fedorenko, Toshchakova, Boyarko, Semke, Bokhan, and Ivanova); National Research Tomsk Polytechnic University, Tomsk, Siberia, Russian Federation (Drs Fedorenko and Ivanova); Department of Pharmacy, University of Groningen, Groningen, The Netherlands (Dr Loonen); Mental Health Institute Westelijk Noord-Brabant, Halsteren, The Netherlands (Dr Loonen); Department of Physiology, University of Tuebingen, Tuebingen, Germany (Dr Lang); Chita State Medical Academy, Chita, Siberia, Russian Federation (Dr Govorin); National Research Tomsk State University, Tomsk, Siberia, Russian Federation (Dr Bokhan); Scientific Research Institute of Physiology and Basic Medicine, Siberian Branch of RAMSc, Novosibirsk, Siberia, Russian Federation (Dr Aftanas).

Nikolay V GovorinMental Health Research Institute, SiberianBranch of RAMSc, Tomsk, Siberia, Russian Federation (Drs Fedorenko, Toshchakova, Boyarko, Semke, Bokhan, and Ivanova); National Research Tomsk Polytechnic University, Tomsk, Siberia, Russian Federation (Drs Fedorenko and Ivanova); Department of Pharmacy, University of Groningen, Groningen, The Netherlands (Dr Loonen); Mental Health Institute Westelijk Noord-Brabant, Halsteren, The Netherlands (Dr Loonen); Department of Physiology, University of Tuebingen, Tuebingen, Germany (Dr Lang); Chita State Medical Academy, Chita, Siberia, Russian Federation (Dr Govorin); National Research Tomsk State University, Tomsk, Siberia, Russian Federation (Dr Bokhan); Scientific Research Institute of Physiology and Basic Medicine, Siberian Branch of RAMSc, Novosibirsk, Siberia, Russian Federation (Dr Aftanas).

Lyubomir I AftanasMental Health Research Institute, SiberianBranch of RAMSc, Tomsk, Siberia, Russian Federation (Drs Fedorenko, Toshchakova, Boyarko, Semke, Bokhan, and Ivanova); National Research Tomsk Polytechnic University, Tomsk, Siberia, Russian Federation (Drs Fedorenko and Ivanova); Department of Pharmacy, University of Groningen, Groningen, The Netherlands (Dr Loonen); Mental Health Institute Westelijk Noord-Brabant, Halsteren, The Netherlands (Dr Loonen); Department of Physiology, University of Tuebingen, Tuebingen, Germany (Dr Lang); Chita State Medical Academy, Chita, Siberia, Russian Federation (Dr Govorin); National Research Tomsk State University, Tomsk, Siberia, Russian Federation (Dr Bokhan); Scientific Research Institute of Physiology and Basic Medicine, Siberian Branch of RAMSc, Novosibirsk, Siberia, Russian Federation (Dr Aftanas).

Svetlana A IvanovaMental Health Research Institute, SiberianBranch of RAMSc, Tomsk, Siberia, Russian Federation (Drs Fedorenko, Toshchakova, Boyarko, Semke, Bokhan, and Ivanova); National Research Tomsk Polytechnic University, Tomsk, Siberia, Russian Federation (Drs Fedorenko and Ivanova); Department of Pharmacy, University of Groningen, Groningen, The Netherlands (Dr Loonen); Mental Health Institute Westelijk Noord-Brabant, Halsteren, The Netherlands (Dr Loonen); Department of Physiology, University of Tuebingen, Tuebingen, Germany (Dr Lang); Chita State Medical Academy, Chita, Siberia, Russian Federation (Dr Govorin); National Research Tomsk State University, Tomsk, Siberia, Russian Federation (Dr Bokhan); Scientific Research Institute of Physiology and Basic Medicine, Siberian Branch of RAMSc, Novosibirsk, Siberia, Russian Federation (Dr Aftanas).

GGZ Westelijk Noord-Brabant · NLUniversity of Groningen · NLUniversity of Tübingen · DEMental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences · RUTomsk Polytechnic University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTardive dyskinesia is a disorder characterized by involuntary muscle movements that occur as a complication of long-term treatment with antipsychotic drugs. It has been suggested to be related to a malfunctioning of the indirect pathway of the motor part of the cortical-striatal-thalamic-cortical circuit, which may be caused by oxidative stress-induced neurotoxicity.

methodsThe purpose of our study was to investigate the possible association between phosphatidylinositol-4-phosphate-5-kinase type IIa (PIP5K2A) function and tardive dyskinesia in 491 Caucasian patients with schizophrenia from 3 different psychiatric institutes in West Siberia. The Abnormal Involuntary Movement Scale was used to assess tardive dyskinesia. Individuals were genotyped for 3 single nucleotide polymorphisms in PIP5K2A gene: rs10828317, rs746203, and rs8341.

resultsA significant association was established between the functional mutation N251S-polymorphism of the PIP5K2A gene (rs10828317) and tardive dyskinesia, while the other 2 examined nonfunctional single nucleotide polymorphisms were not related.

conclusionsWe conclude from this association that PIP5K2A is possibly involved in a mechanism protecting against tardive dyskinesia-inducing neurotoxicity. This corresponds to our hypothesis that tardive dyskinesia is related to neurotoxicity at striatal indirect pathway medium-sized spiny neurons.

Indexed as

Polymorphism, Single NucleotideAdultAntipsychotic AgentsDyskinesia, Drug-InducedFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleMiddle AgedMovement DisordersPhenotypePhosphotransferases (Alcohol Group Acceptor)Protective FactorsRisk AssessmentAntipsychotic AgentsPhosphotransferases (Alcohol Group Acceptor)PIP4K2A protein, humangene polymorphismmedium spiny neuronsneurotoxicityPIP5K2Aschizophreniatardive dyskinesia

Identifiers

PMID25548108

DOI10.1093/ijnp/pyu098

PMCPMC4438543

OpenAlexW2094246939

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.