ArticleThe international journal of neuropsychopharmacology2014
Increased excitability of lateral habenula neurons in adolescent rats following cocaine self-administration.
Article in The international journal of neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Transcriptional regulation of ventral hippocampus-nucleus accumbens circuit excitability drives cocaine seeking.Science advances · 2026Article
- Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking.Nature communications · 2024Article
- Compulsive drug-taking is associated with habenula-frontal cortex connectivity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Circuits and functions of the lateral habenula in health and in disease.Nature reviews. Neuroscience · 2020Review
- Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research.Frontiers in behavioral neuroscience · 2020Review
- From controlled to compulsive drug-taking: The role of the habenula in addiction.Neuroscience and biobehavioral reviews · 2019Review
- Cocaine withdrawal reduces GABAThe European journal of neuroscience · 2019Article
- Cell-type and projection-specific dopaminergic encoding of aversive stimuli in addiction.Brain research · 2019Review
- A role for corticotropin-releasing factor signaling in the lateral habenula and its modulation by early-life stress.Science signaling · 2018Article
- Ketamine Reverses Lateral Habenula Neuronal Dysfunction and Behavioral Immobility in the Forced Swim Test Following Maternal Deprivation in Late Adolescent Rats.Frontiers in synaptic neuroscience · 2018Article
- A Focus on Reward Prediction and the Lateral Habenula: Functional Alterations and the Behavioral Outcomes Induced by Drugs of Abuse.Frontiers in synaptic neuroscience · 2018Review
- Inhibition of AMPA receptor and CaMKII activity in the lateral habenula reduces depressive-like behavior and alcohol intake in rats.Neuropharmacology · 2017Article
- Control of behavioral flexibility by the lateral habenula.Pharmacology, biochemistry, and behavior · 2017Review
- An emerging role for the lateral habenula in aggressive behavior.Pharmacology, biochemistry, and behavior · 2017Review
- Translating the Habenula-From Rodents to Humans.Biological psychiatry · 2017Review
- Temporal variations in presynaptic release probability in the lateral habenula.Scientific reports · 2017Article
- High Frequency Electrical Stimulation of Lateral Habenula Reduces Voluntary Ethanol Consumption in Rats.The international journal of neuropsychopharmacology · 2016Article
- Insights into the Role of the Habenular Circadian Clock in Addiction.Frontiers in psychiatry · 2015Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe lateral habenula is a brain region that has been critically implicated in modulating negative emotional states and responses to aversive stimuli. Exposure to addictive drugs such as cocaine negatively impacts affective states, an effect persisting longer than acute drug effects. However, the mechanisms of this effect are poorly understood. We hypothesized that drugs of abuse, such as cocaine, may contribute to drug-induced negative affective states by altering the firing properties of lateral habenula neurons, thus changing the signaling patterns from the lateral habenula to downstream circuits.
methodsUsing whole-cell current-clamp recording of acutely prepared brain slices of rats after various periods of withdrawal from cocaine self-administration, we characterized an important heterogeneous subregion of the lateral habenula based on membrane properties.
resultsWe found two major relevant neuronal subtypes: burst firing neurons and regular spiking neurons. We also found that lateral habenula regular spiking neurons had higher membrane excitability for at least 7 days following cocaine self-administration, likely due to a greater membrane resistance. Both the increase in lateral habenula excitability and membrane resistance returned to baseline when tested after a more prolonged period of 45 days of withdrawal.
conclusionThis is the first study to look at intrinsic lateral habenula neuron properties following cocaine exposure beyond acute drug effects. These results may help to explain how cocaine and other drugs negatively impact affect states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.