ArticleApplied and environmental microbiology2015
Impact of the use of β-lactam antimicrobials on the emergence of Escherichia coli isolates resistant to cephalosporins under standard pig-rearing conditions.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Antibiotic resistance of fecal carriage of Escherichia coli from pig farms in China: a meta-analysis.Environmental science and pollution research international · 2022Pooled it
- Antimicrobial Use and Epidemiological Resistance Profiles of CommensalAntibiotics (Basel, Switzerland) · 2026Article
- Article
- In vitro assessment of the synergistic effects of cefotaxime, colistin, and fosfomycin combinations against foodborne resistant Escherichia coli and Salmonella isolates.The Journal of antibiotics · 2025Article
- Prevalence and genetic basis of extended-spectrum β-lactamase-producingFrontiers in veterinary science · 2025Article
- Multidrug resistance inApplied and environmental microbiology · 2024Article
- Characterization of Antimicrobial Resistance inAnimals : an open access journal from MDPI · 2024Article
- Antimicrobial Resistance in CommensalAntibiotics (Basel, Switzerland) · 2023Review
- Intestinal Exposure to Ceftiofur and Cefquinome after Intramuscular Treatment and the Impact of Ceftiofur on the Pig Fecal Microbiome and Resistome.Antibiotics (Basel, Switzerland) · 2022Article
- Risk Factors for Antimicrobial Use on Irish Pig Farms.Animals : an open access journal from MDPI · 2021Article
- Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Methods for the Quantification of Cefquinome, Ceftiofur, and Desfuroylceftiofuracetamide in Porcine Feces with Emphasis on Analyte Stability.Molecules (Basel, Switzerland) · 2021Article
- Role played by the environment in the emergence and spread of antimicrobial resistance (AMR) through the food chain.EFSA journal. European Food Safety Authority · 2021Article
- An efficient cephalosporin stewardship programme in French swine production.Veterinary medicine and science · 2021Article
- High β-lactam resistance in Gram-negative bacteria associated with kennel cough and cat flu in Egypt.Scientific reports · 2021Article
- Foraging at Solid Urban Waste Disposal Sites as Risk Factor for Cephalosporin and Colistin ResistantFrontiers in microbiology · 2020Article
- Advances in the Analysis of Veterinary Drug Residues in Food Matrices by Capillary Electrophoresis Techniques.Molecules (Basel, Switzerland) · 2019Review
- Amplification of Antimicrobial Resistance in Gut Flora of Patients Treated with Ceftriaxone.Antimicrobial agents and chemotherapy · 2017Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate if the treatments with ceftiofur and amoxicillin are risk factors for the emergence of cephalosporin resistant (CR) E. coli in a pig farm during the rearing period. One hundred 7-day-old piglets were divided into two groups, a control (n = 50) group and a group parenterally treated with ceftiofur (n = 50). During the fattening period, both groups were subdivided in two. A second treatment with amoxicillin was administered in feed to two of the four groups, as follows: group 1 (untreated, n = 20), group 2 (treated with amoxicillin, n = 26), group 3 (treated with ceftiofur, n = 20), and group 4 (treated with ceftiofur and amoxicillin, n = 26). During treatment with ceftiofur, fecal samples were collected before treatment (day 0) and at days 2, 7, 14, 21, and 42 posttreatment, whereas with amoxicillin, the sampling was extended 73 days posttreatment. CR E. coli bacteria were selected on MacConkey agar with ceftriaxone (1 mg/liter). Pulsed-field gel electrophoresis (PFGE), MICs of 14 antimicrobials, the presence of cephalosporin resistance genes, and replicon typing of plasmids were analyzed. Both treatments generated an increase in the prevalence of CR E. coli, which was statistically significant in the treated groups. Resistance diminished after treatment. A total of 47 CR E. coli isolates were recovered during the study period; of these, 15 contained blaCTX-M-1, 10 contained blaCTX-M-14, 4 contained blaCTX-M-9, 2 contained blaCTX-M-15, and 5 contained blaSHV-12. The treatment with ceftiofur and amoxicillin was associated with the emergence of CR E. coli during the course of the treatment. However, by the time of finishing, CR E. coli bacteria were not recovered from the animals.
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