Evidence map›Paper›PMID 25547887›Full record

ArticleJournal of pediatric rehabilitation medicine2014

Isokinetic muscle strength differences in patients with mucopolysaccharidosis I, II, and VI.

Natalie E Taylor, Donald R Dengel, Troy C Lund, Kyle D Rudser, Paul J Orchard, Julia Steinberger, Chester B Whitley, Lynda E Polgreen

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric rehabilitation medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01870375 (Longitudinal Studies of Brain Structure and Function in MPS Disorders), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01870375 completednot on this map

Longitudinal Studies of Brain Structure and Function in MPS Disorders

TypeobservationalSponsorUniversity of MinnesotaRan2009 to 2019Enrolled100ConditionsMucopolysaccharidosis Type I, Mucopolysaccharidosis Type II, Mucopolysaccharidosis Type VI, Mucopolysaccharidosis Type IV
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natalie E TaylorSchool of Medicine and Public Health, University of Wisconsin, WI, USA.
Donald R DengelSchool of Kinesiology, University of Minnesota, Minneapolis, MN, USA Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Troy C LundDivision of Pediatric Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Kyle D RudserDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Paul J OrchardDivision of Pediatric Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Julia SteinbergerDivision of Pediatric Cardiology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Chester B WhitleyDivision of Pediatric Genetics and Metabolism, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Lynda E PolgreenDivision of Pediatric Endocrinology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Training & EducationU54NS065768 · NINDS · UNIVERSITY OF MINNESOTA · PI WHITLEY, CHESTER B. · 2009 to 2024
$17.7M
Perivascular Cell Characterization and Contribution to the Hematopoietic NicheK08HL108998 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUND, TROY C. · 2011 to 2015
$686k
Natural History of Bone Disease and the Impact of Growth Hormone Treatment in MPSK23AR057789 · NIAMS · UNIVERSITY OF MINNESOTA · PI POLGREEN, LYNDA ELIZABETH · 2010 to 2013
$534k
NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1TR000114NHLBI NIH HHS K08 HL108998NIAMS NIH HHS K23 AR057789NIAMS NIH HHS K23AR057789NINDS NIH HHS U54 NS065768NINDS NIH HHS U54NS065768
6 · The paper itself

Abstract

purposeTo determine muscular strength differences in patients with MPS-I, II, and VI versus age- and sex-matched healthy controls.

methodsDominant leg isokinetic knee extension strength was measured at 90 and 120 degrees per second (d/s) using a dynamometer in 30 subjects with MPS and 42 controls (5-16 yrs). MPS-I was further divided into MPS-IA (attenuated) and MPS-IH (severe). Strength measures analyzed were peak torque (PkT), peak torque per unit body weight (PkT/BW) and per unit lean body mass (PkT/LBM), and average power (AP).

resultsFollowing adjusting strength measures for age, MPS-IH and MPS-II had significantly lower strength measures for all variables at both angular velocities. MPS-VI had significantly lower PkT, PkT/LBM, and AP compared to controls at 90 and 120d/s. In contrast, MPS-IA was not significantly different from controls for any strength variable at either angular velocity.

conclusionThe results of this study suggest that decrements in skeletal muscle strength depend on MPS diagnosis and severity of disease. Children with MPS-IH demonstrate the greatest difference in muscular strength compared to healthy controls.

Indexed as

Muscle StrengthAdolescentCase-Control StudiesChildChild, PreschoolCohort StudiesFemaleHumansKnee JointMaleMucopolysaccharidosis IMucopolysaccharidosis IIMucopolysaccharidosis VIMuscle, SkeletalSeverity of Illness IndexTorqueisokineticMucopolysaccharidosisstrength

Identifiers

PMID25547887
PMCPMC4438747

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.