ArticlePathology oncology research : POR2015
Correlations between prognosis and regional biomarker profiles in head and neck squamous cell carcinomas.
Article in Pathology oncology research : POR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Associations between FDG-PET and Ki 67-index in head and neck cancer: A meta-analysis.Medicine · 2019Pooled it
- Comprehensive Immunophenotypic Profiling and Prognostic Value in Salivary Gland Mucoepidermoid Carcinoma.International dental journal · 2026Article
- Deep learning model using contrast-enhanced CT for predicting overall survival in oropharyngeal squamous cell carcinoma: a prospective multicenter study.European radiology · 2026Article
- [Overall survival, organ preservation, function preservation: the role of surgery in the treatment of laryngeal cancer].Magyar onkologia · 2025Review
- Potential Prognostic Role of Protein Kinase D Isoforms in Head and Neck Cancers.International journal of molecular sciences · 2024Article
- Article
- MEK Is a Potential Indirect Target in Subtypes of Head and Neck Cancers.International journal of molecular sciences · 2023Article
- Patient delay and its clinical significance among head and neck cancer patients in Hungary.Pathology oncology research : POR · 2023Article
- Predicting the Proliferation of Tongue Cancer With Artificial Intelligence in Contrast-Enhanced CT.Frontiers in oncology · 2022Article
- A Study of Prognostic Factors in Young Patients With Non-HPV Oral Cancer in Central Europe.Pathology oncology research : POR · 2021Article
- Proteomic analysis of hypopharyngeal and laryngeal squamous cell carcinoma sheds light on differences in survival.Scientific reports · 2020Article
- Sequential immunohistochemistry and virtual image reconstruction using a single slide for quantitative KI67 measurement in breast cancer.Breast (Edinburgh, Scotland) · 2020Article
- Roles of Ki-67 and p16 as biomarkers for unknown primary head and neck squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Article
- Ras and Rap1: A tale of two GTPases.Seminars in cancer biology · 2019Review
- Downregulation of Calcium-Binding Protein S100A9 Inhibits Hypopharyngeal Cancer Cell Proliferation and Invasion Ability Through Inactivation of NF-κB Signaling.Oncology research · 2017Article
- Review
- Lipid nanoemulsions and liposomes improve photodynamic treatment efficacy and tolerance in CAL-33 tumor bearing nude mice.Journal of nanobiotechnology · 2016Article
- PITX1 is a novel predictor of the response to chemotherapy in head and neck squamous cell carcinoma.Molecular and clinical oncology · 2016Article
- Copy number gain of PIK3CA and MET is associated with poor prognosis in head and neck squamous cell carcinoma.Virchows Archiv : an international journal of pathology · 2016Article
- Methylation status of insulin-like growth factor-binding protein 7 concurs with the malignance of oral tongue cancer.Journal of experimental & clinical cancer research : CR · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Head and neck squamous cell carcinomas (HNSCC) show diverse clinicopathological features and are mostly linked with poor outcome. In this study, we tested if the expression of tumor growth, cell cycle and basement membrane anchorage related biomarkers allow prognostic and clinicopathological stratification of HNSCC. Archived HNSCC samples from 226 patients included into tissue microarrays (TMA) were tested using immunohistochemistry. Histopathological evaluation and the analysis of immunostaining for EGFR, Ki67, p53, p16(ink4) and Collagen XVII proteins were carried out in digital whole slides. Statistical evaluation was carried out using Pearson's Chi-square test and Kaplan-Meier survival analysis. In the tested cohort, hypopharyngeal cancers had the least favorable, and glottic cancers had the most favorable prognosis. High Ki67 positive tumor cell fractions were associated with significantly worse prognosis and elevated rate of lymph node metastasis. Both Ki67 and EGFR expression correlated significantly with the tumor localization. Ki67 index was the highest in the hypopharyngeal region and it proved to be the lowest in the glottic region. EGFR expression was the highest in the oral cavity and the lowest in the glottic region. The survival rate of patients with p16(ink4)-negative cancer was significantly lower than of those with p16(ink4)-positive disease. A significant inverse correlation was found between histological grade and the prognosis of HNSCC. Our data support that elevated Ki67 positive proliferating cell fractions contribute to the unfavorable prognosis of hypopharyngeal cancers, while glottic cancers have the most favorable prognosis because of the lowest Ki67 expression rate.
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