Trial reportNeuroRehabilitation2015
Feasibility of using high-definition transcranial direct current stimulation (HD-tDCS) to enhance treatment outcomes in persons with aphasia.
Trial report in NeuroRehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03805659 (High-Definition Transcranial Direct Current Stimulation), which is not on this map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
High-Definition Transcranial Direct Current Stimulation (HD-tDCS) in Logopenic Variant Primary Progressive Aphasia (lvPPA): Effects on Language and Neural Mechanisms
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The use of noninvasive brain stimulation techniques to improve reading difficulties in dyslexia: A systematic review.Human brain mapping · 2022Pooled it
- Transcranial direct current stimulation (tDCS) for improving aphasia in adults with aphasia after stroke.The Cochrane database of systematic reviews · 2019Pooled it
- Clinical Comparison between HD-tDCS and tDCS for Improving Upper Limb Motor Function: A Randomized, Double-Blinded, Sham-Controlled Trial.Neural plasticity · 2024Trial
- Transcranial Direct Current Stimulation Paired With Verb Network Strengthening Treatment Improves Verb Naming in Primary Progressive Aphasia: A Case Series.American journal of speech-language pathology · 2022Trial
- High-definition transcranial direct current stimulation (HD-tDCS) of left dorsolateral prefrontal cortex affects performance in Balloon Analogue Risk Task (BART).Brain and behavior · 2018Trial
- Stimulation of Dorsolateral Prefrontal Cortex Enhances Adaptive Cognitive Control: A High-Definition Transcranial Direct Current Stimulation Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Trial
- BDNF genotype and tDCS interaction in aphasia treatment.Brain stimulationTrial
- Exploring the Effects of a Computerized Naming Intervention Combined with Cerebellar tDCS in Cantonese-Speaking Individuals with Aphasia.Brain sciences · 2026Article
- Simulating tDCS-induced electric fields in stroke patients: Realistic-lesion head models are needed.NeuroImage. Clinical · 2026Article
- Article
- Rapid cortical mapping with cross-participant encoding models.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Military applications of transcranial direct current stimulation (tDCS) for enhanced multitasking performance.Cognitive research: principles and implications · 2025Review
- HD-tDCS improves conflict processing and general behavioral stability.Scientific reports · 2025Article
- On the Effects of Non-Invasive Brain Stimulation Techniques on Developmental Dyslexia: A Systematic Review of Randomized Controlled Trials.Iranian journal of psychiatry · 2025Review
- A review on the reporting and assessment of adverse effects associated with high-definition transcranial direct current stimulation.Frontiers in human neuroscience · 2025Review
- Individualized connectomic tACS immediately improves oscillatory network with language facilitation in post-stroke aphasia: a feasibility study of a dysfunctome-based targeting approach.Frontiers in computational neuroscience · 2025Article
- Early Boost of Linguistic Skills? Individualized Non-Invasive Brain Stimulation in Early Postacute Aphasia.Brain sciences · 2024Article
- Article
- Targeted neurorehabilitation strategies in post-stroke aphasia.Restorative neurology and neuroscience · 2023Review
- Optimized high-definition tDCS in patients with skull defects and skull plates.Frontiers in human neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundTranscranial direct current stimulation (tDCS) enhances treatment outcomes post-stroke. Feasibility and tolerability of high-definition (HD) tDCS (a technique that increases current focality and intensity) for consecutive weekdays as an adjuvant to behavioral treatment in a clinical population has not been demonstrated.
objectiveTo determine HD-tDCS feasibility outcomes: 1) ability to implement study as designed, 2) acceptability of repeated HD-tDCS administration to patients, and 3) preliminary efficacy.
methodsEight patients with chronic post-stroke aphasia participated in a randomized crossover trial with two arms: conventional sponge-based (CS) tDCS and HD-tDCS. Computerized anomia treatment was administered for five consecutive days during each treatment arm.
resultsIndividualized modeling/targeting procedures and an 8-channel HD-tDCS device were developed. CS-tDCS and HD-tDCS were comparable in terms of implementation, acceptability, and outcomes. Naming accuracy and response time improved for both stimulation conditions. Change in accuracy of trained items was numerically higher (but not statistically significant) for HD-tDCS compared to CS-tDCS for most patients.
conclusionsRegarding feasibility, HD-tDCS treatment studies can be implemented when designed similarly to documented CS-tDCS studies. HD-tDCS is likely to be acceptable to patients and clinicians. Preliminary efficacy data suggest that HD-tDCS effects, using only 4 electrodes, are at least comparable to CS-tDCS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.