ArticleThe Journal of cell biology2015
Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability.
Article in The Journal of cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- A comprehensive review of histone modifications during mammalian oogenesis and early embryo development.Histochemistry and cell biology · 2025Review
- DCMS analysis revealed differential selection signatures in the transboundary Sahiwal cattle for major economic traits.Scientific reports · 2025Article
- Prognostic assessment of early-stage liver cirrhosis induced by HCV using an integrated model of CX3CR1-associated immune infiltration genes.Scientific reports · 2025Article
- Reproductive genomics of the mouse: implications for human fertility and infertility.Development (Cambridge, England) · 2023Article
- Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p.Communications biology · 2022Article
- Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.Nature communications · 2022Article
- Identification of bromodomain-containing proteins prognostic value and expression significance based on a genomic landscape analysis of ovarian serous cystadenocarcinoma.Frontiers in oncology · 2022Article
- Clinical detection, diagnosis and treatment of morphological abnormalities of sperm flagella: A review of literature.Frontiers in genetics · 2022Review
- Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis.Development (Cambridge, England) · 2021Article
- HDAC3 controls male fertility through enzyme-independent transcriptional regulation at the meiotic exit of spermatogenesis.Nucleic acids research · 2021Article
- Bi-allelic BRWD1 variants cause male infertility with asthenoteratozoospermia and likely primary ciliary dyskinesia.Human genetics · 2021Article
- Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition.Nature structural & molecular biology · 2020Article
- Article
- Testis-specific serine kinase protein family in male fertility and as targets for non-hormonal male contraception†.Biology of reproduction · 2020Review
- Genetic dissection of reproductive performance of dairy cows under heat stress.Animal genetics · 2020Article
- Prioritizing candidate genes for fertility in dairy cows using gene-based analysis, functional annotation and differential gene expression.BMC genomics · 2019Article
- Filtered reproductive long non-coding RNAs by genome-wide analyses of goat ovary at different estrus periods.BMC genomics · 2018Article
- Directions and applications of CRISPR technology in livestock research.Animal reproduction · 2018Article
- A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation.Genes & development · 2017Article
- In silico prediction of novel therapeutic targets using gene-disease association data.Journal of translational medicine · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Postmeiotic gene expression is essential for development and maturation of sperm and eggs. We report that the dual bromodomain-containing protein BRWD1, which is essential for both male and female fertility, promotes haploid spermatid-specific transcription but has distinct roles in oocyte meiotic progression. Brwd1 deficiency caused down-regulation of ∼300 mostly spermatid-specific transcripts in testis, including nearly complete elimination of those encoding the protamines and transition proteins, but was not associated with global epigenetic changes in chromatin, which suggests that BRWD1 acts selectively. In females, Brwd1 ablation caused severe chromosome condensation and structural defects associated with abnormal telomere structure but only minor changes in gene expression at the germinal vesicle stage, including more than twofold overexpression of the histone methyltransferase MLL5 and LINE-1 elements transposons. Thus, loss of BRWD1 function interferes with the completion of oogenesis and spermatogenesis through sexually dimorphic mechanisms: it is essential in females for epigenetic control of meiotic chromosome stability and in males for haploid gene transcription during postmeiotic sperm differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.