ArticleBMC plant biology2014
Major haplotype divergence including multiple germin-like protein genes, at the wheat Sr2 adult plant stem rust resistance locus.
Article in BMC plant biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
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- Wheat improvement through advances in single nucleotide polymorphism (SNP) detection and genotyping with a special emphasis on rust resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
- High-density mapping of durable and broad-spectrum stripe rust resistance gene Yr30 in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Intelligent reprogramming of wheat for enhancement of fungal and nematode disease resistance using advanced molecular techniques.Frontiers in plant science · 2023Review
- Wheat Genes Associated with Different Types of Resistance against Stem Rust (Pathogens (Basel, Switzerland) · 2022Review
- The Use and Limitations of Exome Capture to Detect Novel Variation in the Hexaploid Wheat Genome.Frontiers in plant science · 2022Article
- Characterization and Use in Wheat Breeding of Leaf Rust Resistance Genes from Durable Varieties.Biology · 2021Article
- A wheat cysteine-rich receptor-like kinase confers broad-spectrum resistance against Septoria tritici blotch.Nature communications · 2021Article
- Fine mapping QSc.VR4, an effective and stable scald resistance locus in barley (Hordeum vulgare L.), to a 0.38-Mb region enriched with LRR-RLK and GLP genes.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Divergence between bread wheat and Triticum militinae in the powdery mildew resistance QPm.tut-4A locus and its implications for cloning of the resistance gene.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- Rapid gene cloning in cereals.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Review
- Chromosome-scale comparative sequence analysis unravels molecular mechanisms of genome dynamics between two wheat cultivars.Genome biology · 2018Article
- Extensive gene content variation in the Brachypodium distachyon pan-genome correlates with population structure.Nature communications · 2017Article
- Inferring defense-related gene families in Arabidopsis and wheat.BMC genomics · 2017Article
- Rapid cloning of genes in hexaploid wheat using cultivar-specific long-range chromosome assembly.Nature biotechnology · 2017Article
- Repeat-length variation in a wheat cellulose synthase-like gene is associated with altered tiller number and stem cell wall composition.Journal of experimental botany · 2017Article
- Article
- Suppressed recombination and unique candidate genes in the divergent haplotype encoding Fhb1, a major Fusarium head blight resistance locus in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- Haplotype divergence and multiple candidate genes at Rphq2, a partial resistance QTL of barley to Puccinia hordei.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
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13 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe adult plant stem rust resistance gene Sr2 was introgressed into hexaploid wheat cultivar (cv) Marquis from tetraploid emmer wheat cv Yaroslav, to generate stem rust resistant cv Hope in the 1920s. Subsequently, Sr2 has been widely deployed and has provided durable partial resistance to all known races of Puccinia graminis f. sp. tritici. This report describes the physical map of the Sr2-carrying region on the short arm of chromosome 3B of cv Hope and compares the Hope haplotype with non-Sr2 wheat cv Chinese Spring.
resultsSr2 was located to a region of 867 kb on chromosome 3B in Hope, which corresponded to a region of 567 kb in Chinese Spring. The Hope Sr2 region carried 34 putative genes but only 17 were annotated in the comparable region of Chinese Spring. The two haplotypes differed by extensive DNA sequence polymorphisms between flanking markers as well as by a major insertion/deletion event including ten Germin-Like Protein (GLP) genes in Hope that were absent in Chinese Spring. Haplotype analysis of a limited number of wheat genotypes of interest showed that all wheat genotypes carrying Sr2 possessed the GLP cluster; while, of those lacking Sr2, some, including Marquis, possessed the cluster, while some lacked it. Thus, this region represents a common presence-absence polymorphism in wheat, with presence of the cluster not correlated with presence of Sr2. Comparison of Hope and Marquis GLP genes on 3BS found no polymorphisms in the coding regions of the ten genes but several SNPs in the shared promoter of one divergently transcribed GLP gene pair and a single SNP downstream of the transcribed region of a second GLP.
conclusionPhysical mapping and sequence comparison showed major haplotype divergence at the Sr2 locus between Hope and Chinese Spring. Candidate genes within the Sr2 region of Hope are being evaluated for the ability to confer stem rust resistance. Based on the detailed mapping and sequencing of the locus, we predict that Sr2 does not belong to the NB-LRR gene family and is not related to previously cloned, race non-specific rust resistance genes Lr34 and Yr36.
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