Evidence map›Paper›PMID 25547070›Full record

SynthesisClinical biomechanics (Bristol, Avon)2015

Anterior cruciate ligament biomechanics during robotic and mechanical simulations of physiologic and clinical motion tasks: a systematic review and meta-analysis.

Nathaniel A Bates, Gregory D Myer, Jason T Shearn, Timothy E Hewett

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical biomechanics (Bristol, Avon), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  15. Ultrasound-Mediated Gene Delivery Enhances Tendon Allograft Integration in Mini-Pig Ligament Reconstruction.Molecular therapy : the journal of the American Society of Gene Therapy · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nathaniel A BatesDepartment of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA; The Sports Health and Performance Institute, OSU Sports Medicine, The Ohio State University, Columbus, OH, USA; Sports Medicine Biodynamics Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Gregory D MyerSports Medicine Biodynamics Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA; Department Orthopaedic Surgery, College of Medicine, University of Cincinnati, OH, USA; Athletic Training Division, School of Allied Medical Professions, The Ohio State University, Columbus, OH, USA.
Jason T ShearnDepartment of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA.
Timothy E HewettDepartment of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA; The Sports Health and Performance Institute, OSU Sports Medicine, The Ohio State University, Columbus, OH, USA; Sports Medicine Biodynamics Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA; Departments of Physiology and Cell Biology, Orthopaedic Surgery, Family Medicine and Biomedical Engineering, The Ohio State University, Columbus, OH, USA. Electronic address: hewett.12@osu.edu.

Funding

Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female AthletesR01AR055563 · NIAMS · OHIO STATE UNIVERSITY · PI BATES, NATHANIEL ANDREW, KRYCH, AARON · 2008 to 2022
$5.9M
Multi-faceted Approach to Modeling ACL Injury MechanismsR01AR056259 · NIAMS · OHIO STATE UNIVERSITY · PI HEWETT, TIMOTHY E · 2009 to 2017
$4.9M
IDENTIFYING FEMALE ATHLETES AT HIGH RISK FOR ACL INJURYR01AR049735 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI HEWETT, TIMOTHY E · 2004 to 2008
$2.6M
NIAMS NIH HHS R01 AR049735NIAMS NIH HHS R01-AR049735NIAMS NIH HHS R01 AR055563NIAMS NIH HHS R01-AR055563NIAMS NIH HHS R01 AR056259NIAMS NIH HHS R01-AR056259PHS HHS R03-057551
6 · The paper itself

Abstract

Investigators use in vitro joint simulations to invasively study the biomechanical behaviors of the anterior cruciate ligament. The aims of these simulations are to replicate physiologic conditions, but multiple mechanisms can be used to drive in vitro motions, which may influence biomechanical outcomes. The objective of this review was to examine, summarize, and compare biomechanical evidence related to anterior cruciate ligament function from in vitro simulations of knee motion. A systematic review was conducted (2004 to 2013) in Scopus, PubMed/Medline, and SPORTDiscus to identify peer-reviewed studies that reported kinematic and kinetic outcomes from in vitro simulations of physiologic or clinical tasks at the knee. Inclusion criteria for relevant studies were articles published in English that reported on whole-ligament anterior cruciate ligament mechanics during the in vitro simulation of physiologic or clinical motions on cadaveric knees that were unaltered outside of the anterior-cruciate-ligament-intact, -deficient, and -reconstructed conditions. A meta-analysis was performed to synthesize biomechanical differences between the anterior-cruciate-ligament-intact and reconstructed conditions. 77 studies met our inclusion/exclusion criteria and were reviewed. Combined joint rotations have the greatest impact on anterior cruciate ligament loads, but the magnitude by which individual kinematic degrees of freedom contribute to ligament loading during in vitro simulations is technique-dependent. Biomechanical data collected in prospective, longitudinal studies corresponds better with robotic-manipulator simulations than mechanical-impact simulations. Robotic simulation indicated that the ability to restore intact anterior cruciate ligament mechanics with anterior cruciate ligament reconstructions was dependent on loading condition and degree of freedom examined.

Indexed as

Anterior Cruciate LigamentAnterior Cruciate Ligament ReconstructionBiomechanical PhenomenaHumansJoint InstabilityKnee JointMovementProspective StudiesRoboticsStress, MechanicalWeight-BearingAnterior cruciate ligament reconstructionJoint motion simulationKnee injury preventionKnee kinetics and kinematicsKnee ligament mechanicsRobotic manipulation of joints

Identifiers

PMID25547070
PMCPMC4298459

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.