ArticleIEEE transactions on bio-medical engineering2015
Microbubbles and blood-brain barrier opening: a numerical study on acoustic emissions and wall stress predictions.
Article in IEEE transactions on bio-medical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Acoustic Bubble Sensing Techniques and Bioapplications.Biosensors · 2026Review
- Dissipative Particle Dynamics Models of Encapsulated Microbubbles and Nanoscale Gas Vesicles for Biomedical Ultrasound Simulations.ACS applied nano materials · 2025Article
- Microbubble dynamics in brain microvessels.PloS one · 2025Article
- Numerical simulation study on opening blood-brain barrier by ultrasonic cavitation.Ultrasonics sonochemistry · 2024Article
- Machine Learning-Empowered Real-Time Acoustic Trapping: An Enabling Technique for Increasing MRI-Guided Microbubble Accumulation.Sensors (Basel, Switzerland) · 2024Article
- Ultrasound frequency-controlled microbubble dynamics in brain vessels regulate the enrichment of inflammatory pathways in the blood-brain barrier.Nature communications · 2024Article
- Characterization of Blood-Brain Barrier Opening Induced by Transcranial Histotripsy in Murine Brains.Ultrasound in medicine & biology · 2024Article
- Sonoselective delivery using ultrasound and microbubbles combined with intravenous rAAV9 CLDN5-GFP does not increase endothelial gene expression.Gene therapy · 2023Article
- Weakly nonlinear focused ultrasound in viscoelastic media containing multiple bubbles.Ultrasonics sonochemistry · 2023Article
- Weakly nonlinear propagation of focused ultrasound in bubbly liquids with a thermal effect: Derivation of two cases of Khokolov-Zabolotskaya-Kuznetsoz equations.Ultrasonics sonochemistry · 2022Article
- A 3D finite element model to study the cavitation induced stresses on blood-vessel wall during the ultrasound-only phase of photo-mediated ultrasound therapy.AIP advances · 2022Article
- "Focused Ultrasound-mediated Drug Delivery in Humans - a Path Towards Translation in Neurodegenerative Diseases".Pharmaceutical research · 2022Review
- Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound.Advanced drug delivery reviews · 2022Review
- Therapeutic Agent Delivery Across the Blood-Brain Barrier Using Focused Ultrasound.Annual review of biomedical engineering · 2021Review
- Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery.Ultrasound in medicine & biology · 2020Review
- Therapeutic Potentials of Localized Blood-Brain Barrier Disruption by Noninvasive Transcranial Focused Ultrasound: A Technical Review.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2020Review
- Localized Blood-Brain Barrier Opening in Ovine Model Using Image-Guided Transcranial Focused Ultrasound.Ultrasound in medicine & biology · 2019Article
- Advances in acoustic monitoring and control of focused ultrasound-mediated increases in blood-brain barrier permeability.The British journal of radiology · 2019Review
- Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability.Expert opinion on drug delivery · 2019Review
- MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain.Methods in molecular biology (Clifton, N.J.) · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Focused ultrasound with microbubbles is an emerging technique for blood-brain barrier opening. Here, a comprehensive theoretical model of a bubble-fluid-vessel system has been developed which accounts for the bubble's nonspherical oscillations inside a microvessel, and its resulting acoustic emissions. Numerical simulations of unbound and confined encapsulated bubbles were performed to evaluate the effect of the vessel wall on acoustic emissions and vessel wall stresses. Using a Marmottant shell model, the normalized second harmonic to fundamental emissions first decreased as a function of pressure (>50 kPa) until reaching a minima ("transition point") at which point they increased. The transition point of unbound compared to confined bubble populations occurred at different pressures and was associated with an accompanying increase in shear and circumferential wall stresses. As the wall stresses depend on the bubble to vessel wall distance, the stresses were evaluated for bubbles with their wall at a constant distance to a flat wall. As a result, the wall stresses were bubble size and frequency dependent and the peak stress values induced by bubbles larger than resonance remained constant versus frequency at a constant mechanical index.
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