Evidence map›Paper›PMID 25546604›Full record

ArticleMolecular nutrition & food research2015

Gene-dietary fat interaction, bone mineral density and bone speed of sound in children: a twin study in China.

Tao Huang, Huijuan Liu, Wei Zhao, Ji Li, Youfa Wang

Open access · greenAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Tao HuangDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Huijuan Liu
Wei Zhao
Ji Li
Youfa Wang
Johns Hopkins University · USFirst Hospital of Jiaxing · CN

Funding

MULTILEVEL SYSTEMS-ORIENTED CHILDHOOD OBESITY STUDY IN CHINAU54HD070725 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CURRIERO, FRANK · 2011 to 2016
$15.9M
Diabetes Research and Training CenterP60DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WONDISFORD, FREDRIC E. · 2008 to 2012
$9.1M
Causes and Interventions for Childhood Obesity:Innovative Systems AnalysisR01HD064685 · NICHD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WANG, YOUFA · 2010 to 2013
$1.2M
Understanding Disparities in Obesity and its Comorbidities in the USR01DK081335 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WANG, YOUFA · 2009 to 2010
$1.2M
NICHD NIH HHS 1R01HD064685-01A1NICHD NIH HHS R01 HD064685NICHD NIH HHS U54 HD070725NICHD NIH HHS U54 HD070725-01NIDDK NIH HHS P60 DK0079637NIDDK NIH HHS P60 DK079637NIDDK NIH HHS R01 DK081335NIDDK NIH HHS R01DK81335-01A1
6 · The paper itself

Abstract

scopeDietary fat correlates with bone mineral density (BMD). We tested the association between fat intake and BMD, and tested if fat intake modified the degree of genetic influence on BMD and bone speed of sound (SOS). METHODS AND

resultsWe included 622 twins aged 7-15 from South China. Data on anthropometry, dietary intake, BMD, and SOS were collected. Quantitative genetic analyses of structural equation models were fit using the Mx statistical package. The within-pair intraclass correlations for BMD in dizygotic twins were nearly half of that for monozygotic twins (intraclass correlations = 0.39 versus 0.70). The heritability of BMD and SOS were 71 and 79%. Phenotypic correlation between fat intake and SOS was significant (r = -0.19, p = 0.04). SOS was negatively correlated with fat intake in boys (r = -0.11, p = 0.05), but not in girls. Full Cholesky decomposition models showed SOS has a strong genetic correlation with fat intake (rA = -0.88, 95% confidence interval = -0.94, 0.01); the environmental correlation between fat intake and SOS was weak (rE = -0.04, 95% confidence interval = -0.20, 0.13). Fat intake modified the additive genetic effects on BMD.

conclusionGenetic factors explained 71 and 79% of individual variance in BMD and SOS, respectively. Low fat intake counteracts genetic predisposition to low BMD.

Indexed as

AdolescentBone and BonesBone DensityChildChinaDietary FatsFemaleGene-Environment InteractionHumansMalePhenotypeTwins, DizygoticTwins, MonozygoticUltrasonographyDietary FatsBone mineral densityDietary fatGene-diet interactionHeritabilityTwin study

Identifiers

PMID25546604
PMCPMC4539945
OpenAlexW1972470855

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.