ArticleeLife2014
Genetic transformation of structural and functional circuitry rewires the Drosophila brain.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Lineages to circuits: the developmental and evolutionary architecture of information channels into the central complex.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Review
- Neural architectures in the light of comparative connectomics.Current opinion in neurobiology · 2021Review
- The role of cell lineage in the development of neuronal circuitry and function.Developmental biology · 2021Review
- Article
- Understanding brain development - Indian researchers' past, present and growing contribution.The International journal of developmental biology · 2020Review
- Pioneer interneurons instruct bilaterality in the Drosophila olfactory sensory map.Science advances · 2019Article
- A question of lineage.eLife · 2019Article
- Rewiring theFrontiers in molecular neuroscience · 2019Review
- Patterns of growth and tract formation during the early development of secondary lineages in the Drosophila larval brain.Developmental neurobiology · 2016Article
- Transcriptomes of lineage-specific Drosophila neuroblasts profiled by genetic targeting and robotic sorting.Development (Cambridge, England) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
Acquisition of distinct neuronal identities during development is critical for the assembly of diverse functional neural circuits in the brain. In both vertebrates and invertebrates, intrinsic determinants are thought to act in neural progenitors to specify their identity and the identity of their neuronal progeny. However, the extent to which individual factors can contribute to this is poorly understood. We investigate the role of orthodenticle in the specification of an identified neuroblast (neuronal progenitor) lineage in the Drosophila brain. Loss of orthodenticle from this neuroblast affects molecular properties, neuroanatomical features, and functional inputs of progeny neurons, such that an entire central complex lineage transforms into a functional olfactory projection neuron lineage. This ability to change functional macrocircuitry of the brain through changes in gene expression in a single neuroblast reveals a surprising capacity for novel circuit formation in the brain and provides a paradigm for large-scale evolutionary modification of circuitry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.