ArticleThe European journal of neuroscience2015
Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates.
Article in The European journal of neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Association learning drives synaptic plasticity at feedforward synapses in somatosensory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Nonlinear Asymmetric Blood Oxygenation Level Dependent Responses in Somatosensory Cortex.Human brain mapping · 2026Article
- Transient enhancement of stimulus-evoked activity in neocortex during sensory learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- An automated homecage system for multiwhisker detection and discrimination learning in mice.PloS one · 2020Article
- Review
- Article
- The complexity of understanding others as the evolutionary origin of empathy and emotional contagion.Scientific reports · 2019Article
- High-velocity stimulation evokes "dense" population response in layer 2/3 vibrissal cortex.Journal of neurophysiology · 2017Article
- Characterisation of sensitivity and orientation tuning for visually responsive ensembles in the zebrafish tectum.Scientific reports · 2016Article
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Authors and funding
2 authors.
Funding
Abstract
Although subthreshold inputs of neocortical sensory neurons are broadly tuned, the spiking output is more restricted. These subthreshold inputs provide a substrate for stimulus intensity-dependent changes their spiking output, as well as for experience-dependent plasticity to alter firing properties. Here we investigated how different stimulus intensities modified the firing output of individual neurons in layer 2/3 of the mouse barrel cortex. Decreasing stimulus intensity over a 30-fold range lowered the firing rates evoked by principal whisker stimulation and reduced the overall size of the responding ensemble in whisker-undeprived animals. We then examined how these responses were changed after single-whisker experience (SWE). After 7 days of SWE, the mean magnitude of response to spared whisker stimulation at the highest stimulus intensity was not altered. However, lower-intensity whisker stimulation revealed a more than 10-fold increase in mean firing output compared with control animals. Also, under control conditions, only ~15% of neurons showed any firing at low stimulus intensity, compared with more than 70% of neurons after SWE. However, response changes measured in the immediately surrounding representations were detected only for the highest stimulus intensity. Overall, these data showed that the measurement of experience-dependent changes in the spike output of neocortical neurons was highly dependent upon stimulus intensity.
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Registered trials
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