ArticleToxicology and applied pharmacology2015
Early life exposure to allergen and ozone results in altered development in adolescent rhesus macaque lungs.
Article in Toxicology and applied pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Early-Life Ozone Exposure and Asthma and Wheeze in Children.JAMA network open · 2025Article
- Alteration of glycosphingolipid metabolism by ozone is associated with exacerbation of allergic asthma characteristics in mice.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Airway remodeling: TheFrontiers in allergy · 2022Review
- Outdoor Air Pollution and New-Onset Airway Disease. An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2020Article
- Ozone-induced enhancement of airway hyperreactivity in rhesus macaques: Effects of antioxidant treatment.The Journal of allergy and clinical immunology · 2020Article
- Pulmonary Neuroendocrine Cells Secrete γ-Aminobutyric Acid to Induce Goblet Cell Hyperplasia in Primate Models.American journal of respiratory cell and molecular biology · 2019Article
- Development of a large-scale computer-controlled ozone inhalation exposure system for rodents.Inhalation toxicology · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
In rhesus macaques, previous studies have shown that episodic exposure to allergen alone or combined with ozone inhalation during the first 6 months of life results in a condition with many of the hallmarks of asthma. This exposure regimen results in altered development of the distal airways and parenchyma (Avdalovic et al., 2012). We hypothesized that the observed alterations in the lung parenchyma would be permanent following a long-term recovery in filtered air (FA) housing. Forty-eight infant rhesus macaques (30 days old) sensitized to house dust mite (HDM) were treated with two week cycles of FA, house dust mite allergen (HDMA), ozone (O3) or HDMA/ozone (HDMA+O3) for five months. At the end of the five months, six animals from each group were necropsied. The other six animals in each group were allowed to recover in FA for 30 more months at which time they were necropsied. Design-based stereology was used to estimate volumes of lung components, number of alveoli, size of alveoli, distribution of alveolar volumes, interalveolar capillary density. After 30 months of recovery, monkeys exposed to HDMA, in either group, had significantly more alveoli than filtered air. These alveoli also had higher capillary densities as compared with FA controls. These results indicate that early life exposure to HDMA alone or HDMA+O3 alters the development process in the lung alveoli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.