Evidence map›Paper›PMID 25545744›Full record

Trial reportThe Prostate2015

Randomized clinical trial of brewed green and black tea in men with prostate cancer prior to prostatectomy.

Susanne M Henning, Piwen Wang, Jonathan W Said, Min Huang, Tristan Grogan, David Elashoff, Catherine L Carpenter, David Heber, William J Aronson

Registry-linked trialOpen access · greenAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Prostate, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00685516 (Effects of Brewed Green and Black Tea on Inflammation, Apoptosis and Oxidation in Men With Prostate Cancer), which is not on this map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00685516 nacompletednot on this map

Effects of Brewed Green and Black Tea on Inflammation, Apoptosis and Oxidation in Men With Prostate Cancer

TypeinterventionalSponsorJonsson Comprehensive Cancer CenterRan2007 to 2015Enrolled113ConditionsProstate CancerArmsgreen tea, placebo, decaffeinated black tea
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 87 citations in OpenAlex.

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  3. Effect of green tea and lycopene on the insulin-like growth factor system: the ProDiet randomized controlled trial.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Susanne M HenningCenter for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA.
Piwen Wang
Jonathan W Said
Min Huang
Tristan Grogan
David Elashoff
Catherine L Carpenter
David Heber
William J Aronson
University of California, Los Angeles · USVA Greater Los Angeles Healthcare System · USCharles R. Drew University of Medicine and Science · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA SPORE IN PROSTATE CANCERP50CA092131 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREEMAN, MICHAEL R · 2002 to 2023
$42.6M
NATIONAL NEUROLOGICAL AIDS BANKU24MH100929 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 2013 to 2023
$12.5M
National Neurological AIDS BankU01MH083500 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 2008 to 2012
$7.2M
Tea Polyphenols in Chemoprevention of Prostate CancerR01CA116242 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HENNING, SUSANNE MARGARETE · 2007 to 2011
$1.3M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCI NIH HHS P30 CA016042NCI NIH HHS P50 CA092131NCI NIH HHS P50CA092131NCI NIH HHS R01 CA116242NIMH NIH HHS U01 MH083500NIMH NIH HHS U24 MH100929
6 · The paper itself

Abstract

backgroundPreclinical and epidemiologic studies suggest chemopreventive effects of green tea (GT) and black tea (BT) in prostate cancer. In the current study we determined the effect of GT and BT consumption on biomarkers related to prostate cancer development and progression.

methodsIn this exploratory, open label, phase II trial 113 men diagnosed with prostate cancer were randomized to consume six cups daily of brewed GT, BT or water (control) prior to radical prostatectomy (RP). The primary endpoint was prostate tumor markers of cancer development and progression determined by tissue immunostaining of proliferation (Ki67), apoptosis (Bcl-2, Bax, Tunel), inflammation (nuclear and cytoplasmic nuclear factor kappa B [NFκB]) and oxidation (8-hydroxydeoxy-guanosine [8OHdG]). Secondary endpoints of urinary oxidation, tea polyphenol uptake in prostate tissue, and serum prostate specific antigen (PSA) were evaluated by high performance liquid chromatography and ELISA analysis.

resultsNinety three patients completed the intervention. There was no significant difference in markers of proliferation, apoptosis and oxidation in RP tissue comparing GT and BT to water control. Nuclear staining of NFκB was significantly decreased in RP tissue of men consuming GT (P = 0.013) but not BT (P = 0.931) compared to water control. Tea polyphenols were detected in prostate tissue from 32 of 34 men consuming GT but not in the other groups. Evidence of a systemic antioxidant effect was observed (reduced urinary 8OHdG) only with GT consumption (P = 0.03). GT, but not BT or water, also led to a small but statistically significant decrease in serum prostate-specific antigen (PSA) levels (P = 0.04).

conclusionGiven the GT-induced changes in NFκB and systemic oxidation, and uptake of GT polyphenols in prostate tissue, future longer-term studies are warranted to further examine the role of GT for prostate cancer prevention and treatment, and possibly for other prostate conditions such as prostatitis.

Indexed as

PhytotherapyProstatectomy8-Hydroxy-2'-DeoxyguanosineAdultAgedApoptosisBiomarkers, TumorDeoxyguanosineDisease ProgressionHumansImmunohistochemistryKi-67 AntigenMaleMiddle AgedNF-kappa BPlant Extracts8-Hydroxy-2'-DeoxyguanosineBiomarkers, TumorDeoxyguanosineKi-67 AntigenNF-kappa BPlant ExtractsPolyphenolsProstate-Specific AntigenTeabaxBcl-2nuclear factor kappa Bphase II clinical intervention study

Identifiers

PMID25545744
PMCPMC4334734
OpenAlexW2116619120

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.