ArticleThe Journal of physiology2015
Asian women have attenuated sympathetic activation but enhanced renal-adrenal responses during pregnancy compared to Caucasian women.
Article in The Journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Muscle sympathetic nerve activity during pregnancy: A systematic review and meta-analysis.Physiological reports · 2023Pooled it
- Cardiac output and peripheral vascular resistance during normotensive and hypertensive pregnancy - a systematic review and meta-analysis.BJOG : an international journal of obstetrics and gynaecology · 2022Pooled it
- Impact of Gestational Weight Gain and Maternal Weight on Sympathetic Adaptations.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Longitudinal changes in cardiovascular and sympathetic neural responses to static handgrip exercise throughout pregnancy.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- The sympathetic nervous system in healthy and hypertensive pregnancies: physiology or pathology?Experimental physiology · 2023Review
- Differential regulation of sympathetic neural burst frequency and amplitude throughout normal pregnancy: a longitudinal study.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Sympathetic Action Potential Firing and Recruitment Patterns Are Abnormal in Gestational Hypertension.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Posture-related changes in sympathetic baroreflex sensitivity during normal pregnancy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Neural control of blood pressure during pregnancy in humans.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Review
- Sympathetic nervous system activity and reactivity in women with gestational diabetes mellitus.Physiological reports · 2020Article
- Influence of multiparity on sympathetic nerve activity during normal pregnancy.American journal of physiology. Heart and circulatory physiology · 2020Article
- Cell-free mitochondrial DNA increases in maternal circulation during healthy pregnancy: a prospective, longitudinal study.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Observational
- Adaptations in autonomic nervous system regulation in normal and hypertensive pregnancy.Handbook of clinical neurology · 2020Review
- Cuff inflation time significantly affects blood flow recorded with venous occlusion plethysmography.European journal of applied physiology · 2019Article
- Role of Corin in Blood Pressure Regulation in Normotensive and Hypertensive Pregnancy.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Activity of muscle sympathetic neurons during normotensive pregnancy.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Muscle sympathetic nerve activity peaks in the first trimester in healthy pregnancy: a longitudinal case study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2017Article
- Autonomic control of body temperature and blood pressure: influences of female sex hormones.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2017Review
- Sympathetic neural and cardiovascular responses during static handgrip exercise in women with a history of hypertensive pregnancy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016Article
- Sympathetic baroreflex gain in normotensive pregnant women.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
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Abstract
Asians have a lower prevalence of hypertensive disorders of pregnancy than Caucasians. Since sympathetic overactivity and dysregulation of the renal-adrenal system (e.g. low aldosterone levels) have been found in preeclamptic women, we hypothesized that Asians have lower muscle sympathetic nerve activity (MSNA) and greater aldosterone concentrations during normal pregnancy than Caucasians. In a prospective study, blood pressure (BP), heart rate (HR), and MSNA were measured during supine and upright tilt (30 deg and 60 deg for 5 min each) in 9 Asians (32 ± 1 years (mean ± SEM)) and 12 Caucasians (29 ± 1 years) during pre-, early (≤8 weeks of gestation) and late (32-36 weeks) pregnancy, and post-partum (6-10 weeks after delivery). Supine MSNA increased with pregnancy in both groups (P < 0.001); it was significantly lower in Asians than Caucasians (14 ± 3 vs. 23 ± 3 bursts min(-1) and 16 ± 5 vs. 30 ± 3 bursts min(-1) in early and late pregnancy, respectively; P = 0.023). BP decreased during early pregnancy (P < 0.001), but was restored during late pregnancy. HR increased during pregnancy (P < 0.001) with no racial difference (P = 0.758). MSNA increased during tilting and it was markedly lower in Asians than Caucasians in late pregnancy (31 ± 6 vs. 49 ± 3 bursts min(-1) at 60 deg tilt; P = 0.003). Upright BP was lower in Asians, even in pre-pregnancy (P = 0.006), and this racial difference persisted during pregnancy. Direct renin and aldosterone increased during pregnancy (both P < 0.001); these hormones were greater in Asians (P = 0.086 and P = 0.014). Thus, Asians have less sympathetic activation but more upregulated renal-adrenal responses than Caucasians during pregnancy. These results may explain, at least in part, why Asian women are at low risk of hypertensive disorders in pregnancy.
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