Evidence map›Paper›PMID 25545441›Full record

Trial reportAmerican journal of perinatology2015

Antenatal corticosteroids for preterm premature rupture of membranes: single or repeat course?

Kathleen F Brookfield, Yasser Y El-Sayed, Lisa Chao, Victoria Berger, Mariam Naqvi, Alexander J Butwick

Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of perinatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02939742 (Does a Repeat Course of Antenatal Corticosteroids in Pregnant Women With Preterm Premature Rupture of Membranes Decrease Neonatal Morbidity?), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02939742 phase2 / phase3terminatednot on this mapstarted 2016, after this paper: background citation

Does a Repeat Course of Antenatal Corticosteroids in Pregnant Women With Preterm Premature Rupture of Membranes Decrease Neonatal Morbidity?

TypeinterventionalSponsorThe University of Texas Medical Branch, GalvestonRan2016 to 2023Enrolled33ConditionsPPROM, Respiratory Distress Syndrome in Premature InfantsArmsBetamethasone, Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 21 citations in OpenAlex.

  1. Administration of Antenatal Corticosteroids: Optimal Timing.Geburtshilfe und Frauenheilkunde · 2024
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kathleen F BrookfieldDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California.
Yasser Y El-SayedDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California.
Lisa ChaoDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California.
Victoria BergerDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California.
Mariam NaqviDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California.
Alexander J ButwickDepartment of Anesthesia, Stanford University School of Medicine, Stanford, California.
Stanford University · US

Funding

Postpartum Hemmorrhage and Anemia: Epidemiologic and Cost-Effectiveness AnalysesK23HD070972 · NICHD · STANFORD UNIVERSITY · PI BUTWICK, ALEXANDER JAMES · 2013 to 2017
$699k
NICHD NIH HHS 1K23HD070972NICHD NIH HHS K23 HD070972
6 · The paper itself

Abstract

objectiveThe aim of this article is to determine the risk of maternal chorioamnionitis and neonatal morbidity in women with preterm premature rupture of membranes (PPROM) exposed to one corticosteroid course versus a single repeat corticosteroid steroid course. STUDY

designSecondary analysis of a cohort of women with singleton pregnancies and PPROM. The primary outcome was a clinical diagnosis of maternal chorioamnionitis. Using multivariate logistic regression, we controlled for maternal age, race, body mass index, diabetes, gestational age at membrane rupture, preterm labor, and antibiotic administration. Neonatal morbidities were compared between groups controlling for gestational age at delivery.

resultsOf 1,652 women with PPROM, 1,507 women received one corticosteroid course and 145 women received a repeat corticosteroid course. The incidence of chorioamnionitis was similar between groups (single course = 12.3% vs. repeat course = 11.0%; p = 0.8). Women receiving a repeat corticosteroid course were not at increased risk of chorioamnionitis (adjusted odds ratio, 1.28; 95% confidence interval, 0.69-2.14). A repeat course of steroids was not associated with an increased risk of any neonatal morbidity.

conclusionCompared with a single steroid course, our findings suggest that the risk of maternal chorioamnionitis or neonatal morbidity may not be increased for women with PPROM receiving a repeat corticosteroid course.

Indexed as

Adrenal Cortex HormonesChorioamnionitisPremature Rupture of Fetal MembranesAdultCohort StudiesFemaleGestational AgeHumansLogistic ModelsMultivariate AnalysisObstetric Labor, PrematureOdds RatioPregnancyPregnancy OutcomeYoung AdultAdrenal Cortex Hormones

Identifiers

PMID25545441
PMCPMC4460987
OpenAlexW2062023881

What OpenQuestion holds

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LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.