ArticlePloS one2014
Borrelia burgdorferi promotes the establishment of Babesia microti in the northeastern United States.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
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- Temporal Dynamic Interplay of Mouse Proteome during ProtozoanJournal of proteome research · 2025Article
- Functional connectivity for white-tailed deer drives the distribution of tick-borne pathogens in a highly urbanized setting.Landscape ecology · 2025Article
- Prevalence ofMicroorganisms · 2024Article
- Effects of Inosine-5'-monophosphate Dehydrogenase (IMPDH/GuaB) Inhibitors onMicroorganisms · 2024Article
- Host-pathogen associations inferred from bloodmeal analyses ofApplied and environmental microbiology · 2024Article
- Effects of residential acaricide treatments on patterns of pathogen coinfection in blacklegged ticks.Parasitology · 2024Article
- Co-Occurrence ofPathogens (Basel, Switzerland) · 2024Article
- Coinfection ofPathogens (Basel, Switzerland) · 2024Review
- Tick-Borne Co-Infections: Challenges in Molecular and Serologic Diagnoses.Pathogens (Basel, Switzerland) · 2023Review
- Prevalence of five human pathogens in host-seeking Ixodes scapularis and Ixodes pacificus by region, state, and county in the contiguous United States generated through national tick surveillance.Ticks and tick-borne diseases · 2023Article
- Transfusion-transmittedJournal of clinical microbiology · 2023Review
- Tick Densities and Infection Prevalence on Coastal Islands in Massachusetts, USA: Establishing a Baseline.Insects · 2023Article
- Spatiotemporal distribution of Borrelia miyamotoi (Spirochaetales: Spirochaetaceae) and coinfection with other tick-borne pathogens in host-seeking Ixodes scapularis (Acari: Ixodidae) from New York State, USA.Journal of medical entomology · 2023Article
- The Use of Natural Bioactive Nutraceuticals in the Management of Tick-Borne Illnesses.Microorganisms · 2023Review
- Ecological interactions driving population dynamics of two tick-borne pathogens,Proceedings. Biological sciences · 2023Article
- Deployment of a Reservoir-Targeted Vaccine Against Borrelia burgdorferi Reduces the Prevalence of Babesia microti Coinfection in Ixodes scapularis Ticks.The Journal of infectious diseases · 2023Article
11 more citing papers are in PubMed but not listed here.
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12 authors.
Funding
Abstract
Babesia microti and Borrelia burgdorferi, the respective causative agents of human babesiosis and Lyme disease, are maintained in their enzootic cycles by the blacklegged tick (Ixodes scapularis) and use the white-footed mouse (Peromyscus leucopus) as primary reservoir host. The geographic range of both pathogens has expanded in the United States, but the spread of babesiosis has lagged behind that of Lyme disease. Several studies have estimated the basic reproduction number (R0) for B. microti to be below the threshold for persistence (<1), a finding that is inconsistent with the persistence and geographic expansion of this pathogen. We tested the hypothesis that host coinfection with B. burgdorferi increases the likelihood of B. microti transmission and establishment in new areas. We fed I. scapularis larva on P. leucopus mice that had been infected in the laboratory with B. microti and/or B. burgdorferi. We observed that coinfection in mice increases the frequency of B. microti infected ticks. To identify the ecological variables that would increase the probability of B. microti establishment in the field, we integrated our laboratory data with field data on tick burden and feeding activity in an R0 model. Our model predicts that high prevalence of B. burgdorferi infected mice lowers the ecological threshold for B. microti establishment, especially at sites where larval burden on P. leucopus is lower and where larvae feed simultaneously or soon after nymphs infect mice, when most of the transmission enhancement due to coinfection occurs. Our studies suggest that B. burgdorferi contributes to the emergence and expansion of B. microti and provides a model to predict the ecological factors that are sufficient for emergence of B. microti in the wild.
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