ArticleMolecular ecology2015
Stability of the gorilla microbiome despite simian immunodeficiency virus infection.
Article in Molecular ecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Associations and interactions between prokaryotes and other gut biota in non-human primates.Primates; journal of primatology · 2026Review
- Evaluation of Gut Microbiota Stability and Flexibility as a Response to Seasonal Variation in the Wild François' Langurs (Trachypithecus francoisi) in Limestone Forest.Microbiology spectrum · 2023Article
- Article
- The Gombe Ecosystem Health Project: 16 years of program evolution and lessons learned.American journal of primatology · 2022Review
- Gut microbiota of ring-tailed lemurs (Lemur catta) vary across natural and captive populations and correlate with environmental microbiota.Animal microbiome · 2022Article
- Walk on the wild side: SIV infection in African non-human primate hosts-from the field to the laboratory.Frontiers in immunology · 2022Review
- The genetic impact of an Ebola outbreak on a wild gorilla population.BMC genomics · 2021Article
- Shifts in microbial diversity, composition, and functionality in the gut and genital microbiome during a natural SIV infection in vervet monkeys.Microbiome · 2020Article
- Enterotypes of the Gut Microbial Community and Their Response to Plant Secondary Compounds in Plateau Pikas.Microorganisms · 2020Article
- The colonic mucosa-associated microbiome in SIV infection: shift towards Bacteroidetes coincides with mucosal CD4Scientific reports · 2020Article
- Oral microbiome diversity in chimpanzees from Gombe National Park.Scientific reports · 2019Article
- Gut Microbiome Alterations During HIV/SIV Infection: Implications for HIV Cure.Frontiers in microbiology · 2019Review
- Factors influencing bacterial microbiome composition in a wild non-human primate community in Taï National Park, Côte d'Ivoire.The ISME journal · 2018Article
- Gut microbiomes of wild great apes fluctuate seasonally in response to diet.Nature communications · 2018Article
- Assessment of the gorilla gut virome in association with natural simian immunodeficiency virus infection.Retrovirology · 2018Article
- Relationships Between Gastrointestinal Parasite Infections and the Fecal Microbiome in Free-Ranging Western Lowland Gorillas.Frontiers in microbiology · 2018Article
- Destabilization of the gut microbiome marks the end-stage of simian immunodeficiency virus infection in wild chimpanzees.American journal of primatology · 2018Article
- Enterotypes in the landscape of gut microbial community composition.Nature microbiology · 2018Review
- A Summary of the Second Annual HIV Microbiome Workshop.AIDS research and human retroviruses · 2017Article
- Stress and stability: applying the Anna Karenina principle to animal microbiomes.Nature microbiology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
Abstract
Simian immunodeficiency viruses (SIVs) have been discovered in over 45 primate species; however, the pathogenic potential of most SIV strains remains unknown due to difficulties inherent in observing wild populations. Because those SIV infections that are pathogenic have been shown to induce changes in the host's gut microbiome, monitoring the microbiota present in faecal samples can provide a noninvasive means for studying the effects of SIV infection on the health of wild-living primates. Here, we examine the effects of SIVgor, a close relative of SIVcpz of chimpanzees and HIV-1 of humans, on the gut bacterial communities residing within wild gorillas, revealing that gorilla gut microbiomes are exceptionally robust to SIV infection. In contrast to the microbiomes of HIV-1-infected humans and SIVcpz-infected chimpanzees, SIVgor-infected gorilla microbiomes exhibit neither rises in the frequencies of opportunistic pathogens nor elevated rates of microbial turnover within individual hosts. Regardless of SIV infection status, gorilla microbiomes assort into enterotypes, one of which is compositionally analogous to those identified in humans and chimpanzees. The other gorilla enterotype appears specialized for a leaf-based diet and is enriched in environmentally derived bacterial genera. We hypothesize that the acquisition of this gorilla-specific enterotype was enabled by lowered immune system control over the composition of the microbiome. Our results indicate differences between the pathology of SIVgor and SIVcpz/HIV-1 infections, demonstrating the utility of investigating host microbial ecology as a means for studying disease in wild primates of high conservation priority.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.