Evidence map›Paper›PMID 25544963›Full record

SynthesisTheScientificWorldJournal2014

Correlations of ezrin expression with pathological characteristics and prognosis of osteosarcoma: a meta-analysis.

Da-Hang Zhao, Jiang Zhu, Wen-Bo Wang, Feng Dong, Qiao Zhang, Hong-Wu Fan, Jing-Zhe Zhang, Yong-Ming Wang

RetractedOpen access · goldAbstract readMeta-AnalysisReviewRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Da-Hang Zhao3rd Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Harbin 150001, China.
Jiang Zhu3rd Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Harbin 150001, China.
Wen-Bo Wang3rd Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Harbin 150001, China.
Feng Dong4th Department of Orthopedics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Qiao ZhangDepartment of Orthopedics, China Japan Union Hospital of Jilin University, Changchun 130033, China.
Hong-Wu FanDepartment of Orthopedics, China Japan Union Hospital of Jilin University, Changchun 130033, China.
Jing-Zhe ZhangDepartment of Orthopedics, China Japan Union Hospital of Jilin University, Changchun 130033, China.
Yong-Ming WangDepartment of Orthopedics, China Japan Union Hospital of Jilin University, Changchun 130033, China.
First Affiliated Hospital of Harbin Medical University · CNJilin University · CNUnion Hospital · CNFourth Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted a meta-analysis to comprehensively evaluate the correlations of ezrin expression with pathological characteristics and the prognosis of osteosarcoma. The MEDLINE (1966-2013), the Cochrane Library Database, EMBASE, CINAHL, Web of Science (1945-2013), and the Chinese Biomedical Database were searched without language restrictions. Meta-analyses conducted using STATA software were calculated. Ten studies met the inclusion criteria, including 459 patients with osteosarcoma. Meta-analysis results illustrated that ezrin expression may be closely associated with the recurrence of osteosarcoma or metastasis in osteosarcoma. Our findings also demonstrated that patients with grade III-IV osteosarcoma showed a higher frequency of ezrin expression than those with histological grade I-II osteosarcoma. Furthermore, we found that patients with positive expression of ezrin exhibited a shorter overall survival than those with negative ezrin expression. The results also indicated that positive ezrin expression was strongly correlated with poorer metastasis-free survival. Nevertheless, no significant relationships were observed between ezrin expression and clinical variables (age and gender). In the current meta-analysis, our results illustrated significant relationships of ezrin expression with pathological characteristics and prognosis of osteosarcoma. Thus, ezrin expression could be a promising marker in predicting the clinical outcome of patients with osteosarcoma.

Indexed as

Bone NeoplasmsGene Expression Regulation, NeoplasticOsteosarcomaCytoskeletal ProteinsDisease-Free SurvivalEzrinFemaleHumansMaleMEDLINENeoplasm GradingNeoplasm MetastasisNeoplasm ProteinsSurvival RateCytoskeletal ProteinsEzrinNeoplasm Proteins

Identifiers

PMID25544963
PMCPMC4270117
OpenAlexW1964357419

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.