Evidence map›Paper›PMID 25544900›Full record

ArticleNeural plasticity2014

Recovery of olfactory function induces neuroplasticity effects in patients with smell loss.

Kathrin Kollndorfer, Ksenia Kowalczyk, Elisabeth Hoche, Christian A Mueller, Michael Pollak, Siegfried Trattnig, Veronika Schöpf

3 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Neural plasticity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 50 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 7 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04710394 nacompletednot on this mapstarted 2021, after this paper: background citation

Efficacy of Bimodal Visual-Olfactory Training in Participants With COVID-19 Resultant Hyposmia or Anosmia Using Participant-Preferred Scents

TypeinterventionalSponsorWashington University School of MedicineRan2021 to 2022Enrolled240ConditionsAnosmia, Covid19, Ageusia, HyposmiaArmsSmell Training
NCT05216614 phase2withdrawnnot on this mapstarted 2021, after this paper: background citation

Fluvoxamine to Augment Olfactory Recovery For Long COVID-19 Parosmia (FluCOP Trial)

TypeinterventionalSponsorWashington University School of MedicineRan2021 to 2022Enrolled0ConditionsCOVID-19, Olfactory Disorder, ParosmiaArmsFluvoxamine, Placebo
NCT05947643 phase2completednot on this mapstarted 2022, after this paper: background citation

Smell in COVID-19 and Efficacy of Nasal Theophylline 3

TypeinterventionalSponsorWashington University School of MedicineRan2022 to 2025Enrolled77ConditionsCOVID-19Armstheophylline, Placebo
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 7 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Pooled it
  2. The efficacy of olfactory training in improving olfactory function: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Pooled it
  3. Pooled it
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  7. Pooled it
  8. Article
  9. Article
  10. Olfactory Dysfunction and Cognitive Decline: Are They Related?Current allergy and asthma reports · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Determination of Aflatoxin BFoods (Basel, Switzerland) · 2024
    Article
  18. Article
  19. Review
  20. Association between cognition and olfaction-specific parameters in patients with chronic rhinosinusitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kathrin KollndorferDepartment of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria ; Department of Pediatric and Adolescent Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.ORCID 0000-0002-5983-5307
Ksenia KowalczykDepartment of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.ORCID 0000-0002-1497-9550
Elisabeth HocheDepartment of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Christian A MuellerDepartment of Otorhinolaryngology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Michael PollakDepartment of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Siegfried TrattnigHigh-Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Veronika SchöpfDepartment of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.ORCID 0000-0003-1937-4216
Medical University of Vienna · AT

Funding

Austrian Science Fund FWF P 23205
6 · The paper itself

Abstract

The plasticity of brain function, especially reorganization after stroke or sensory loss, has been investigated extensively. Based upon its special characteristics, the olfactory system allows the investigation of functional networks in patients with smell loss, as it holds the unique ability to be activated by the sensorimotor act of sniffing, without the presentation of an odor. In the present study, subjects with chronic peripheral smell loss and healthy controls were investigated using functional magnetic resonance imaging (fMRI) to compare functional networks in one of the major olfactory areas before and after an olfactory training program. Data analysis revealed that olfactory training induced alterations in functional connectivity networks. Thus, olfactory training is capable of inducing neural reorganization processes. Furthermore, these findings provide evidence for the underlying neural mechanisms of olfactory training.

Indexed as

Neuronal PlasticityRecovery of FunctionAdultBrainBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetOlfaction DisordersOlfactory Perception

Identifiers

PMID25544900
PMCPMC4269319
OpenAlexW2084911640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.