Evidence map›Paper›PMID 25544886›Full record

ArticleJournal of materials chemistry. B2014

Phospholipase A2-responsive antibiotic delivery via nanoparticle-stabilized liposomes for the treatment of bacterial infection.

Soracha Thamphiwatana, Weiwei Gao, Dissaya Pornpattananangkul, Qiangzhe Zhang, Victoria Fu, Jiayang Li, Jieming Li, Marygorret Obonyo, Liangfang Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials chemistry. B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 116 citations in OpenAlex.

  1. Review
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  14. Review
  15. Synthetic cells in biomedical applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022
    Review
  16. Revisiting Therapeutic Strategies forMolecules (Basel, Switzerland) · 2021
    Review
  17. Review
  18. Soft Materials that Intercept, Respond to, and Sequester Bacterial Siderophores.Chemistry of materials : a publication of the American Chemical Society · 2021
    Article
  19. Review
  20. Smart Nanomaterials for Biomedical Applications-A Review.Nanomaterials (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Soracha ThamphiwatanaDepartment of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA ; Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.
Weiwei GaoDepartment of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA ; Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.
Dissaya PornpattananangkulDepartment of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA ; Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.
Qiangzhe ZhangDepartment of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA.
Victoria FuDepartment of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA ; Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.
Jiayang LiDepartment of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA.
Jieming LiDepartment of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA.
Marygorret ObonyoDepartment of Medicine, University of California, San Diego, La Jolla, California 92093, USA.
Liangfang ZhangDepartment of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA ; Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.
University of California, San Diego · USMoores Cancer Center

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
Innate Antimicrobial Nanotherapeutics for the Treatment of H. pylori InfectionR01DK095168 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHANG, LIANGFANG · 2012 to 2016
$1.6M
NCI NIH HHS P30 CA023100NIDDK NIH HHS R01 DK095168
6 · The paper itself

Abstract

Adsorbing small charged nanoparticles onto liposome surfaces to stabilize them against fusion and payload leakage has resulted in a new class of liposomes capable of environment-responsive drug delivery. Herein, we engineered a liposome formulation with a lipid composition sensitive to bacterium-secreted phospholipase A2 (PLA

Indexed as

antimicrobial deliveryenzyme responsivegold nanoparticleliposomephospholipase

Identifiers

PMID25544886
PMCPMC4276341
OpenAlexW2117702111

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.