ArticleEvidence-based complementary and alternative medicine : eCAM2014
Effects of acupuncture knife on inflammatory factors and pain in third lumbar vertebrae transverse process syndrome model rats.
Article in Evidence-based complementary and alternative medicine : eCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Feasibility, Safety, and Effectiveness of Ultrasound-Guided Acupotomy Treatment for Degenerative Lumbar Spinal Stenosis: A Pilot Randomized Controlled Trial.Journal of pain research · 2026Trial
- Effectiveness of Acupotomy Combined with Epidural Steroid Injection for Lumbosacral Radiculopathy: A Randomized Controlled Pragmatic Pilot Study.Medicina (Kaunas, Lithuania) · 2024Trial
- Effectiveness and safety of combining pharmacopuncture therapy and acupotomy for treating patients with degenerative lumbar spinal stenosis: A pragmatic, assessor-blinded, randomized, controlled trial.Integrative medicine research · 2026Article
- Progress in the Treatment of Adhesive Capsulitis with External Therapies of Traditional Chinese Medicine: A Comprehensive Review.Journal of pain research · 2026Review
- Acupotomy for Military Training-Induced Lumbar Radiculopathy with Sciatica: Protocol of a Randomized Controlled Trial.Journal of pain research · 2025Article
- Confirmation of the third lumbar transverse process syndrome by clinical treatment and magnetic resonance imaging: a case description.Quantitative imaging in medicine and surgery · 2023Article
- Pediatric lumbar disc herniation: a report of two cases and review of the literature.European journal of medical research · 2022Review
- Using magnetic resonance imaging to measure the depth of acupotomy points in the lumbar spine: A retrospective study.Integrative medicine research · 2021Article
- Acupotomy therapy for cervical vertigo: A protocol for a systematic review and meta-analysis.Medicine · 2020Article
- Acupotomy for third lumbar vertebrae transverse process syndrome: A protocol for systematic review.Medicine · 2020Article
- Acupotomy Therapy for Shoulder Adhesive Capsulitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Article
- Acupotomy Therapy for Chronic Nonspecific Neck Pain: A Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- Acupuncture: Emerging evidence for its use as an analgesic (Review).Experimental and therapeutic medicine · 2015Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this paper was to explore the long-term effects and pain relief mechanism of acupuncture knife on third lumbar vertebrae (L3) transverse process syndrome. Forty SD rats were randomized into control, model, electroacupuncture (EA), and acupuncture knife (AK) group. Except control rats, other rats were subjected to an operation to emulate L3 transverse process syndrome. Fourteen days after the operation, EA and AK rats were given electroacupuncture and acupuncture knife treatments, respectively. Fifty-six days after the operation, enzyme-linked immunosorbent assay was used to measure substance P (SP), 5-hydroxytryptamine (5-HT), interleukin-1β (IL-1β), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and transforming growth factor-β (TGF-β) in peripheral blood. The tail flick test was used to observe pain threshold. We found that rats with the simulation operation had significantly higher levels of SP, 5-HT, IL-1, IL-10, TNF-α, and TGF-β, while the AK rats had lower levels. In addition, the pain threshold of AK rats was similar to that of control rats. AK pretreatment could alleviate pain through modulating inflammatory response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.