ArticleReproductive sciences (Thousand Oaks, Calif.)2015
The Effect of an Obesogenic Maternal Environment on Expression of Fetal Umbilical Cord Blood miRNA.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Epigenetic regulation of pediatric and neonatal immune responses.Pediatric research · 2022Review
- Maternal obesity alters C19MC microRNAs expression profile in fetal umbilical cord blood.Nutrition & metabolism · 2020Article
- Identification of microRNA signatures in umbilical cord blood associated with maternal characteristics.PeerJ · 2019Article
- Placental microRNA Expression Is Not Altered by Maternal Obesity and Fetal Overgrowth.AJP reports · 2016Article
- Effects of Maternal Obesity on Fetal Programming: Molecular Approaches.Cold Spring Harbor perspectives in medicine · 2015Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveExposure to maternal obesity in utero predisposes offspring to obesity and metabolic disease. This study investigated whether maternal obesity is associated with alterations in expression of fetal microRNA (miRNA). STUDY
designA cohort study of women with body mass index (BMI) ≥35 kg/m(2) (n = 16) versus those with normal BMI 20 to 24.9 (n = 20) was performed. All participants had normal glucose tolerance (1-hour glucose challenge test <130) and normally grown neonates (2700-3500 g). Umbilical cord samples were collected immediately after delivery. Expression of miRNA was assessed using Affymetrix GeneChip miRNA 3.0 Arrays. Differential miRNA expression was determined using Student t tests with Benjamini-Hocherg correction.
resultsFor 1733 human mature miRNAs, the expression levels were not statistically different in umbilical cord blood samples from pregnancies of obese women compared to controls.
conclusionExpression of fetal miRNA is not altered in umbilical cord blood in response to in utero exposure to obesity. Alternate mechanisms underlying the fetal effects of maternal obesity should be explored.
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Registered trials
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