Observational studyJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2015
Acute effects of viral respiratory tract infections on sputum bacterial density during CF pulmonary exacerbations.
Observational study in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Prevalence and Clinical Impact of Respiratory Viral Infections from the STOP2 Study of Cystic Fibrosis Pulmonary Exacerbations.Annals of the American Thoracic Society · 2024Trial
- Respiratory viral infection is associated with increasedERJ open research · 2026Article
- Acute Pulmonary Exacerbation Phenotypes in Patients with Cystic Fibrosis.Annals of the American Thoracic Society · 2022Article
- Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation.Journal of the Pediatric Infectious Diseases Society · 2022Review
- The Role of Bacterial and Fungal Human Respiratory Microbiota in COVID-19 Patients.BioMed research international · 2021Review
- The Roles of Bacteria and Viruses in Bronchiectasis Exacerbation: A Prospective Study.Archivos de bronconeumologia · 2020Article
- Clinical impact of respiratory virus in pulmonary exacerbations of children with Cystic Fibrosis.PloS one · 2020Article
- Cystic Fibrosis: Fighting Together Against Coronavirus Infection.Frontiers in medicine · 2020Article
- Characteristics and outcomes of oral antibiotic treated pulmonary exacerbations in children with cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2018Article
- Viral-Bacterial Co-infections in the Cystic Fibrosis Respiratory Tract.Frontiers in immunology · 2018Review
- Recent advances in the understanding and management of cystic fibrosis pulmonary exacerbations.F1000Research · 2018Review
- Respiratory Viral Infections in Chronic Lung Diseases.Clinics in chest medicine · 2017Review
- Cystic fibrosis and the war for iron at the host-pathogen battlefront.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAirway proliferation of Pseudomonas aeruginosa bacteria is thought to trigger CF exacerbations and may be affected by the presence of viral infections.
methodsA 2-year prospective study was conducted on 35 adults with CF. P. aeruginosa sputum density was analyzed during stable, exacerbation and post exacerbation assessments. Upon exacerbation, samples were sent for PCR detection of respiratory viruses and the sputum density of P. aeruginosa in patients with a viral infection versus those without was compared.
resultsTwenty-two patients experienced 30 exacerbations during the study period; 50% were associated with a viral infection. There was no change in sputum density of P. aeruginosa from the stable to exacerbation state when measured by quantitative culture or by PCR. Virus-associated exacerbations did not result in significant increases in P. aeruginosa sputum density compared to non-viral exacerbations.
conclusionSputum density of P. aeruginosa was not increased at the time of CF exacerbation and was not influenced by the presence of viral infection.
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