ArticleAnalytical chemistry2015
Combined analysis of the tobacco metabolites cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine.
Article in Analytical chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Validated single urinary assay designed for exposomic multi-class biomarkers of common environmental exposures.Analytical and bioanalytical chemistry · 2022Article
- Characterization of molecularly imprinted polymers for the extraction of tobacco alkaloids and their metabolites in human urine.Biomedical chromatography : BMC · 2022Article
- Simultaneous analysis of urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, N'-nitrosonornicotine, and cotinine by liquid chromatography-tandem mass-spectrometry.Scientific reports · 2021Article
- Harm Perceptions of Tobacco/Nicotine Products and Child Exposure: Differences between Non-Users, Cigarette-Exclusive, and Electronic Cigarette-Exclusive Users.Tobacco use insights · 2021Article
- Can Smoking Cause Differences in Urine Microbiome in Male Patients With Bladder Cancer? A Retrospective Study.Frontiers in oncology · 2021Article
- Analysis of Acrolein-Derived 1, NChemical research in toxicology · 2019Article
- Presence of the Carcinogen N'-Nitrosonornicotine in Saliva of E-cigarette Users.Chemical research in toxicology · 2018Article
- Biomarkers of exposure to new and emerging tobacco delivery products.American journal of physiology. Lung cellular and molecular physiology · 2017Review
- Diagnostic Methods for Detection of Cotinine Level in Tobacco Users: A Review.Journal of clinical and diagnostic research : JCDR · 2016Review
- Sensitive Quantification of Cannabinoids in Milk by Alkaline Saponification-Solid Phase Extraction Combined with Isotope Dilution UPLC-MS/MS.ACS omega · 2016Article
- Stereospecific Metabolism of the Tobacco-Specific Nitrosamine, NNAL.Chemical research in toxicology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Two of the most widely measured compounds in the urine of people who use tobacco products are cotinine, a major metabolite of the addictive constituent nicotine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a metabolite of the powerful lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Thousands of analyses have been reported in the literature, carried out exclusively, to the best of our knowledge, by separate methods. In the study reported here, we have developed a sensitive, accurate, and precise liquid chromatography-electrospray ionization-tandem mass spectrometry-selected reaction monitoring method for the combined analysis of total cotinine (the sum of cotinine and its glucuronide) and total NNAL (the sum of NNAL and its glucuronide). The new method quantifies naturally occurring [(13)C]cotinine to minimize problems associated with the vast differences in concentration of total cotinine and total NNAL in urine. This method should greatly facilitate future determinations of these important compounds.
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Registered trials
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