Evidence map›Paper›PMID 25544107›Full record

ArticleExpert review of respiratory medicine2015

What is the oligoadenylate synthetases-like protein and does it have therapeutic potential for influenza?

John F Alcorn, Saumendra N Sarkar

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Expert review of respiratory medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John F AlcornDepartment of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.
Saumendra N Sarkar

Funding

Influenza A Inhibits TH17 Host Defense Against Bacterial PneumoniaR01HL107380 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALCORN, JOHN F · 2012 to 2024
$5.4M
Novel Modifiers of Toll-like and RIG-like Receptor SignalingU24AI082673 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SARKAR, SAUMENDRA N · 2009 to 2013
$1.5M
NHLBI NIH HHS R01 HL107380NHLBI NIH HHS R01HL107380NIAID NIH HHS AI082673NIAID NIH HHS U24 AI082673
6 · The paper itself

Abstract

Besides its pandemic potential, seasonal influenza infection is associated with an estimated 250,000 to 500,000 deaths worldwide every year. Part of this virulence of influenza virus can be attributed to its ability to evade the host innate immune response. Here, we discuss the possibility of using a recently described mechanism of boosting the innate immunity by oligoadenylate synthetase-like protein, to combat influenza infections.

Indexed as

2',5'-Oligoadenylate SynthetaseAnimalsAntiviral AgentsGenetic TherapyHost-Pathogen InteractionsHumansImmunity, InnateInfluenza, HumanOrthomyxoviridaeRNA, Viral2',5'-Oligoadenylate SynthetaseAntiviral AgentsOASL protein, humanRNA, ViralinfluenzainterferonOASLRIG-I

Identifiers

PMID25544107
PMCPMC4629247

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.