ArticlePsychiatry research2015
Aberrant amygdala intrinsic functional connectivity distinguishes youths with bipolar disorder from those with severe mood dysregulation.
Article in Psychiatry research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Large-scale network dysfunction in the acute state compared to the remitted state of bipolar disorder: A meta-analysis of resting-state functional connectivity.EBioMedicine · 2020Pooled it
- The Status of Irritability in Psychiatry: A Conceptual and Quantitative Review.Journal of the American Academy of Child and Adolescent Psychiatry · 2016Pooled it
- Anatomical and Functional Connectivity of Critical Deep Brain Structures and Their Potential Clinical Application in Brain Stimulation.Journal of clinical medicine · 2023Article
- Resting-state functional connectivity indicators of risk and resilience for self-harm in adolescent bipolar disorder.Psychological medicine · 2023Article
- The association of genetic variation in CACNA1C with resting-state functional connectivity in youth bipolar disorder.International journal of bipolar disorders · 2023Article
- Keeping up with the kids: the value of co-production in the study of irritability in youth depression and its underlying neural circuitry.Frontiers in behavioral neuroscience · 2023Review
- Associations of Irritability With Functional Connectivity of Amygdala and Nucleus Accumbens in Adolescents and Young Adults With ADHD.Journal of attention disorders · 2022Article
- Underlying mechanisms of disruptive mood dysregulation disorder in children: A systematic review by means of research domain criteria.JCPP advances · 2022Review
- Linking irritability and functional brain networks: A transdiagnostic case for expanding consideration of development and environment in RDoC.Neuroscience and biobehavioral reviews · 2021Review
- Cannabis use and resting state functional connectivity in adolescent bipolar disorder.Journal of psychiatry & neuroscience : JPN · 2021Article
- White matter characteristics between amygdala and prefrontal cortex underlie depressive tendency in end stage renal disease patients before the dialysis initiation.Brain imaging and behavior · 2021Article
- A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder.Bipolar disorders · 2021Article
- Across-subjects multiple baseline trial of exposure-based cognitive-behavioral therapy for severe irritability: a study protocol.BMJ open · 2021Article
- Sensory Processing Difficulties in Youths With Disruptive Mood Dysregulation Disorder.Frontiers in psychiatry · 2020Article
- Preliminary mapping of the structural effects of age in pediatric bipolar disorder with multimodal MR imaging.Psychiatry research. Neuroimaging · 2018Article
- Development of White Matter Microstructure and Intrinsic Functional Connectivity Between the Amygdala and Ventromedial Prefrontal Cortex: Associations With Anxiety and Depression.Biological psychiatry · 2017Article
- Empirically derived patterns of psychiatric symptoms in youth: A latent profile analysis.Journal of affective disorders · 2017Article
- Irritability in Children and Adolescents.Annual review of clinical psychology · 2017Review
- Neurobiological Evidence for the Primacy of Mania Hypothesis.Current neuropharmacology · 2017Review
- Abnormal Functional Connectivity Between Default and Salience Networks in Pediatric Bipolar Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
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Authors and funding
8 authors.
Funding
Abstract
It remains unclear the degree to which youths with episodic mania (bipolar disorder; BD) vs. those with chronic, severe irritability (severe mood dysregulation, SMD) should be placed in similar or distinct diagnostic groups. Addressing this clinically meaningful question requires greater understanding of the neural alterations underlying both disorders. We evaluated resting state functional magnetic resonance imaging data of 53 youths (14 BD, 20 healthy volunteers (HV), and 19 SMD, ages 9-18.5 years). Seed regions of interest were the bilateral basolateral, superficial and centromedial amygdala, defined using the Juelich probabilistic atlas. We found a significant between-group difference in functional connectivity between the left basolateral amygdala and the medial aspect of the left frontal pole plus the posterior cingulate/precuneus. This finding was driven by hyperconnectivity among BD vs. HV or SMD youths. As with earlier data, these findings suggest that the pathophysiology of BD and SMD may differ.
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