ArticlePsychopharmacology2015
Effects of circadian disruption on methamphetamine consumption in methamphetamine-exposed rats.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Oxidative and histopathological changes in the hippocampus and prefrontal cortex following light-at-night and methamphetamine exposure.BMC neuroscience · 2026Article
- Adolescent circadian rhythm disruption increases reward and risk-taking.Frontiers in neuroscience · 2024Article
- Circadian disruption and psychostimulants dysregulates plasma acute-phase proteins and circulating cell-free mitochondrial DNA.Brain, behavior, & immunity - health · 2023Article
- Induction of Accelerated Aging in a Mouse Model.Cells · 2022Review
- Sleep dysregulation in binge eating disorder and "food addiction": the orexin (hypocretin) system as a potential neurobiological link.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Review
- Brain activity and transcriptional profiling in mice under chronic jet lag.Scientific data · 2020Article
- Effects of nicotine exposure on oral methamphetamine self-administration, extinction, and drug-primed reinstatement in adolescent male and female rats.Drug and alcohol dependence · 2020Article
- Genome-Wide DNA Methylation Analysis in Male Methamphetamine Users With Different Addiction Qualities.Frontiers in psychiatry · 2020Article
- Heroin self-administration as a function of time of day in rats.Psychopharmacology · 2018Article
- Melatonin in drug addiction and addiction management: Exploring an evolving multidimensional relationship.World journal of psychiatry · 2018Review
- The Clock Gene Rev-Erbα Regulates Methamphetamine Actions on Circadian Timekeeping in the Mouse Brain.Molecular neurobiology · 2017Article
- Circadian Rhythms and Substance Abuse: Chronobiological Considerations for the Treatment of Addiction.Current psychiatry reports · 2017Review
- An animal model of differential genetic risk for methamphetamine intake.Frontiers in neuroscience · 2015Review
- Insights into the Role of the Habenular Circadian Clock in Addiction.Frontiers in psychiatry · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
rationaleA substantial number of clinical studies indicate associations between sleep abnormalities and drug abuse; however, the role played by the circadian system in the development of addiction is largely unknown.
objectiveThe aim of this study was to examine the effects of experimentally induced chronic jet lag on methamphetamine consumption in a rat model of methamphetamine drinking.
methodsMale Sprague-Dawley rats (n = 32) were housed in running wheel cages in a 12:12 h light:dark cycle. One group of rats (n = 16) was given 2 weeks of forced methamphetamine consumption (0.01 % in drinking water; meth pre-exposed) while a second group (n = 16, not pre-exposed) received water only. This was followed by a 2-week abstinence period during which half of the animals from each group were exposed to four consecutive 6-h advancing phase shifts of the light:dark cycle, while the other half remained on the original light:dark cycle. Methamphetamine consumption was assessed in all rats following the deprivation period using a two-bottle choice paradigm.
resultsMethamphetamine consumption was initially lower in methamphetamine pre-exposed versus not pre-exposed rats. However, during the second week following abstinence, consumption was significantly higher in phase-shifted rats of the methamphetamine pre-exposed group compared to all other groups.
conclusionsThese data reveal an effect of circadian rhythm disturbance on methamphetamine consumption and suggest that dysregulation of the circadian system be considered in the etiology of relapse and addiction.
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