ArticleHuman genetics2015
Genetic and environmental components of family history in type 2 diabetes.
Article in Human genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- A nomogram for predicting 5-year incidence of type 2 diabetes in a Chinese population.Endocrine · 2020Trial
- Type 2 Diabetes Mellitus in Saudi Arabia: Prevalence, Risk Factors, and Management Strategies: A Review.Endocrine, metabolic & immune disorders drug targets · 2026Review
- Family member involvement when multiple family members have type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2025Article
- Association between triglyceride-glucose index and the risk of type 2 diabetes mellitus.Archives of endocrinology and metabolism · 2025Article
- Association between the type of family history of diabetes and the risk and age at onset of diabetes in the Japanese general population.Diabetology international · 2025Article
- Genetic Nurture Effects on Type 2 Diabetes Among Chinese Han Adults: A Family-Based Design.Biomedicines · 2025Article
- 3-generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: An open-source catalog of findings.Autism research : official journal of the International Society for Autism Research · 2024Article
- 3-generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: an open-source catalogue of findings.medRxiv : the preprint server for health sciences · 2024Article
- AI-enhanced integration of genetic and medical imaging data for risk assessment of Type 2 diabetes.Nature communications · 2024Article
- Litchi Pericarp Extract Treats Type 2 Diabetes Mellitus by Regulating Oxidative Stress, Inflammatory Response, and Energy Metabolism.Antioxidants (Basel, Switzerland) · 2024Article
- Status of diabetes mellitus in different regions of KSA and update on its management.Frontiers in clinical diabetes and healthcare · 2024Article
- Machine learning for predicting diabetes risk in western China adults.Diabetology & metabolic syndrome · 2023Article
- A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study.Scientific reports · 2023Article
- Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.Nature. Mental health · 2023Article
- Hyperglycemia in Turner syndrome: Impact, mechanisms, and areas for future research.Frontiers in endocrinology · 2023Review
- The Effect ofThe Malaysian journal of medical sciences : MJMS · 2022Review
- Knowledge and practice of diabetic foot care and the prevalence of diabetic foot ulcers among diabetic patients of selected hospitals in the Volta Region, Ghana.International wound journal · 2022Article
- A comparison of negative affect and disinhibited eating between children with and without parents with type 2 diabetes.Pediatric diabetes · 2022Article
- Evaluating the interrelations between the autism polygenic score and psychiatric family history in risk for autism.Autism research : official journal of the International Society for Autism Research · 2022Article
- Body Composition Methods in Adults with Type 2 Diabetes or at Risk for T2D: a Clinical Review.Current diabetes reports · 2021Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Family history of diabetes is a major risk factor for type 2 diabetes (T2D), but whether this association derives from shared genetic or environmental factors is unclear. To address this question, we developed a statistical framework that models four components of variance, including known and unknown genetic and environmental factors, using a liability threshold model. Focusing on parental history, we simulated case-control studies with two first-degree relatives for each individual, assuming 50 % genetic similarity and a range of values of environmental similarity. By comparing the association of parental history with T2D in our simulations to case-control studies of T2D nested in the Nurses' Health Study and Health Professionals Follow-up Study, we estimate that first-degree relatives have a correlation of 23 % (95 % CI 15-27 %) in their environmental contribution to T2D liability and that this shared environment is responsible for 32 % (95 % CI 24-36 %) of the association between parental history and T2D, with the remainder due to shared genetics. Estimates are robust to varying model parameter values and our framework can be extended to different definitions of family history. In conclusion, we find that the association between parental history and T2D derives from predominately genetic but also environmental effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.