ArticleJournal of ovarian research2014
Primordial follicle activation in the ovary of Ames dwarf mice.
Article in Journal of ovarian research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Dynamics of serum exosome microRNA profile altered by chemically induced estropause and rescued by estrogen therapy in female mice.GeroScience · 2024Article
- MASLD does not affect fertility and senolytics fail to prevent MASLD progression in male mice.Scientific reports · 2024Article
- The Clinical Application of Growth Hormone and Its Biological and Molecular Mechanisms in Assisted Reproduction.International journal of molecular sciences · 2022Review
- Growth hormone increases DNA damage in ovarian follicles and macrophage infiltration in the ovaries.GeroScience · 2022Article
- The Interconnections Between Somatic and Ovarian Aging in Murine Models.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Review
- Primordial follicle reserve, DNA damage and macrophage infiltration in the ovaries of the long-living Ames dwarf mice.Experimental gerontology · 2020Article
- 17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates.Experimental gerontology · 2020Article
- Effect of caloric restriction and rapamycin on ovarian aging in mice.GeroScience · 2019Article
- Transcription profile of the insulin-like growth factor signaling pathway during human ovarian follicular development.Journal of assisted reproduction and genetics · 2019Article
- Effects of supplying omega-3 polyunsaturated fatty acids to gilts after weaning on metabolism and ovarian gene expression.Journal of animal science · 2019Article
- FOXO3 Is Expressed in Ovarian Tissues and Acts as an Apoptosis Initiator in Granulosa Cells of Chickens.BioMed research international · 2019Article
- Ovarian aging and the activation of the primordial follicle reserve in the long-lived Ames dwarf and the short-lived bGH transgenic mice.Molecular and cellular endocrinology · 2017Article
- GH and ageing: Pitfalls and new insights.Best practice & research. Clinical endocrinology & metabolism · 2017Review
- Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice.Molecular and cellular endocrinology · 2017Article
- Article
- Growth hormone actions during development influence adult phenotype and longevity.Experimental gerontology · 2016Article
- Healthspan and longevity can be extended by suppression of growth hormone signaling.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- The somatotropic axis and aging: Benefits of endocrine defects.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2016Review
- Reduced growth hormone signaling and methionine restriction: interventions that improve metabolic health and extend life span.Annals of the New York Academy of Sciences · 2016Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe insulin receptor substrate 1 (IRS1), phosphoinositide 3-kinase (Pi3k), protein kinase B (Akt1), Forkhead Box O3a (FOXO3a) pathway is directly involved in aging and ovarian activation of follicle growth. Therefore, the aim of this work was to measure the expression of genes related to the ovarian pathway for activation of primordial follicles and FOXO3a protein phosphorylation between young and old female Ames dwarf (df/df) and normal (N) mice.
methodsFor this study ovaries from N (n = 10) and df/df (n = 10) female mice were collected at 5-6 months of age and at 21-22 months of age. For immunohistochemistry ovaries from 12 month-old and df/df mice were used.
resultsThe expression of Irs1, Pi3k, Akt1, mammalian target of rapamycin (Mtor), suppressor of cytokine signaling -2 (Socs2), Socs3 was lower (P < 0.05) in older than younger N mice and not different (P > 0.05) between young and old df/df mice. The expression of Foxo3a was also lower (P < 0.05) in old than younger N and df/df mice and was higher (P < 0.05) in old df/df than N mice. Expression of Amh was lower (P < 0.05) in old than young N and df/df mice and was higher (P = 0.0009) in df/df than N mice. Imunnostaining for p-FOXO3 was lower in df/df than N mice (P < 0.001), although FOXO3 immunostaining was not different (P > 0.05) between df/df and N mice.
conclusionsIn sum, the present study indicates that lower expression of Irs1, Socs2, Socs3, Akt1, Pi3k, Mtor and Foxo3a mRNA in the ovaries of older mice of both genotypes is associated to a reduced ovarian activity revealed by lower expression of Amh mRNA. At the same time, ovaries of old df/df mice maintained higher expression of Foxo3a mRNA, which was associated to higher ovarian activity. We have shown that df/df females have a lower level of p-FOXO3 in oocytes from primordial/primary follicles, an important activator of follicular growth. Therefore, this study strongly indicates that Prop1(df) mutation causes delayed ovarian aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.