ArticleEnvironmental health and preventive medicine2015
Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study.
Article in Environmental health and preventive medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Exploring diet as a source of plasticizers in pregnancy and implications for maternal second-trimester metabolic health.Environmental research · 2024Article
- Article
- Associations of urinary di(2-ethylhexyl) phthalate metabolites with lipid profiles among US general adult population.Heliyon · 2023Article
- Maternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico.Journal of exposure science & environmental epidemiology · 2022Article
- Exposure to endocrine disrupting chemicals (EDCs) and cardiometabolic indices during pregnancy: The HOME Study.Environment international · 2021Article
- Praegnatio Perturbatio-Impact of Endocrine-Disrupting Chemicals.Endocrine reviews · 2021Review
- Gestational and peripubertal phthalate exposure in relation to attention performance in childhood and adolescence.Environmental research · 2021Article
- Di(2-ethylhexyl) phthalate-induced toxicity and peroxisome proliferator-activated receptor alpha: a review.Environmental health and preventive medicine · 2019Review
- In utero exposure to di(2-ethylhexyl)phthalate suppresses blood glucose and leptin levels in the offspring of wild-type mice.Toxicology · 2019Article
- The Hokkaido Birth Cohort Study on Environment and Children's Health: cohort profile-updated 2017.Environmental health and preventive medicine · 2017Article
- Exposure to phthalates is associated with lipid profile in peripubertal Mexican youth.Environmental research · 2017Article
- Effects of early exposure to phthalates and bisphenols on cardiometabolic outcomes in pregnancy and childhood.Reproductive toxicology (Elmsford, N.Y.) · 2017Review
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe hypolipidemic effects of di(2-ethylhexyl)phthalate (DEHP) exposure in humans have not been investigated. And the influences of maternal prenatal DEHP exposure on birth outcomes are not well-known. We aimed to estimate prenatal DEHP exposure in maternal blood, and evaluate its relationships to maternal blood triglyceride (TG) and fatty acid (FA) levels and to birth outcomes.
methodsWe studied 318 mother-newborn pairs residing in Sapporo, Japan. Blood was taken one time during pregnancy for each mother. Maternal and infant characteristics were obtained from medical records and questionnaire survey. We measured DEHP metabolite, mono(2-ethylhexyl) phthalate (MEHP), along with TG and 9 FAs using maternal blood, and analyzed associations of MEHP level with maternal blood TG/FA levels and infant birth dimensions.
resultsMaternal blood TG and palmitoleic/oleic acid levels were higher, but stearic/docosahexaenoic acids and MEHP were lower during late pregnancy. Maternal blood MEHP levels inversely correlated with TG and palmitic/palmitoleic/oleic/linoleic/α-linolenic acids. After adjustment for confounders, we found that a tenfold increase in blood MEHP levels correlated with a decrease in TG of 25.1 mg/dl [95% confidence interval (CI) 4.8-45.3 mg/dl], and similar relations in palmitic (β = -581.8; 95 % CI -906.5, -257.0), oleic (β = -304.2; 95% CI -518.0, -90.5), linoleic (β = -348.6; 95% CI -510.6, -186.6), and α-linolenic (β = -6.3; 95% CI -9.5, -3.0) acids. However, we observed no correlations between maternal blood MEHP levels and infant birth weight, length, chest circumference, or head circumference.
conclusionsAmbient DEHP exposure during pregnancy inversely correlated with maternal blood TG and 4 FA levels, but not birth outcomes.
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