Evidence map›Paper›PMID 25543118›Full record

ArticleSchizophrenia bulletin2015

Hemispheric language asymmetry in first episode psychosis and schizotypy: the role of cannabis consumption and cognitive disorganization.

Daniela A Herzig, Sarah Sullivan, Glyn Lewis, Rhiannon Corcoran, Richard Drake, Jonathan Evans, David Nutt, Christine Mohr

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PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniela A HerzigClienia AG Littenheid, 9573 Sirnach, CH, Switzerland; Department of Experimental Psychology; Daniela.herzig@clienia.ch.
Sarah SullivanSchool of Social and Community Medicine, University of Bristol, Bristol, UK;
Glyn LewisDepartment of Mental Health, University College London, London, UK;
Rhiannon CorcoranInstitute of Psychology, Health, and Society, University of Liverpool, Liverpool, UK;
Richard DrakePsychiatry Research Group, School of Community Based Medicine, University of Manchester, Manchester, UK;
Jonathan EvansSchool of Social and Community Medicine, University of Bristol, Bristol, UK;
David NuttNeuropsychopharmacology Unit, Imperial College London, London, UK;
Christine MohrDepartment of Experimental Psychology; Faculty of Social Science and Politics, University of Lausanne, CH, Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cannabis use has been related to an elevated psychosis risk and attenuated cognitive functioning. Cannabis-related cognitive impairments are also observed in populations along the psychosis dimension. We here investigated whether a potential behavioral marker of the psychosis dimension (attenuated functional hemispheric asymmetry) is even further attenuated in individuals using cannabis (CU) vs those not using cannabis (nCU). We tested 29 patients with first-episode psychosis (FEP; 11 CU) and 90 healthy controls (38 CU) on lateralized lexical decisions assessing left-hemisphere language dominance. In patients, psychotic symptoms were assessed by Positive & Negative Symptom Scale (PANSS). In controls, self-reported schizotypy was assessed (The Oxford-Liverpool Inventory of Feelings and Experiences: O-LIFE). Results indicated that nCU FEP patients had a relative reduced hemispheric asymmetry, as did controls with increasing cognitive disorganization (CogDis) scores, in particular when belonging to the group of nCU controls. Positive, disorganized and negative PANSS scores in patients and negative and positive schizotypy in controls were unrelated to hemispheric asymmetry. These findings suggest that cannabis use potentially balances rather than exacerbates uncommon hemispheric laterality patterns. Moreover, in healthy populations, the potential stabilization of typical hemispheric asymmetry in CU might be most relevant to individuals with elevated CogDis. We discuss the potential beneficial and harmful effects of cannabis use along the psychosis dimension together with propositions for future studies that should account for the mediating role of additional substances (eg nicotine), cannabis composition (eg cannabidiol content), and individual differences (eg physical health, or absence of significant polysubstance use).

Indexed as

CannabisLanguageAdultFemaleFunctional LateralityHumansMalePsychotic DisordersSchizotypal Personality DisorderYoung Adultcannabiscognitiondrugslateralitypsychosis-pronenessschizotypy

Identifiers

PMID25543118
PMCPMC4373630

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.