ArticleReproductive toxicology (Elmsford, N.Y.)2015
Alteration of mammary gland development and gene expression by in utero exposure to arsenic.
Article in Reproductive toxicology (Elmsford, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The possible role of arsenic and gene-arsenic interactions in susceptibility to breast cancer: a systematic review.Reviews on environmental health · 2021Pooled it
- Article
- The Role of Heavy Metals in the Biology of Female Cancers.International journal of molecular sciences · 2025Review
- Association between urinary arsenic and the prevalence of endometriosis in women in the United States.Frontiers in public health · 2025Article
- Time-specific impact of trace metals on breast density of adolescent girls in Santiago, Chile.International journal of cancer · 2024Article
- Invited Perspective: Metals and Menarche.Environmental health perspectives · 2023Article
- An approach to classifying occupational exposures to endocrine disrupting chemicals by sex hormone function using an expert judgment process.Journal of exposure science & environmental epidemiology · 2021Review
- Arsenite and cadmium promote the development of mammary tumors.Carcinogenesis · 2020Article
- Assessment of YAP gene polymorphisms and arsenic interaction in Mexican women with breast cancer.Journal of applied toxicology : JAT · 2020Article
- Environmental exposures, stem cells, and cancer.Pharmacology & therapeutics · 2019Review
- Arsenic‑induced BRCA1 CpG promoter methylation is associated with the downregulation of ERα and resistance to tamoxifen in MCF7 breast cancer cells and mouse mammary tumor xenografts.International journal of oncology · 2019Article
- Alteration of Mammary Gland Development and Gene Expression by In Utero Exposure to Cadmium.International journal of molecular sciences · 2017Article
- Epigenetics of breast cancer: Modifying role of environmental and bioactive food compounds.Molecular nutrition & food research · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Early life exposure to estrogens and estrogen like contaminants in the environment is thought to contribute to the early onset of puberty and consequently increases the risk of developing breast cancer in the exposed female. The results of this study show that in utero exposure to the metalloestrogen arsenite altered mammary gland development prior to its effect on puberty onset. In the prepubertal gland, in utero exposure resulted in an increase in the number of mammosphere-forming cells and an increase in branching, epithelial cells, and density. In the postpubertal gland, in utero exposure resulted in the overexpression of estrogen receptor-alpha (ERα) that was due to the increased and altered response of the ERα transcripts derived from exons O and OT to estradiol. These results suggest that, in addition to advancing puberty onset, in utero exposure to arsenite alters the pre- and postpubertal development of the mammary gland and possibly, the risk of developing breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.