Evidence map›Paper›PMID 25543061›Full record

ArticleVaccine2015

Anti-group B Streptococcus antibody in infants born to mothers with human immunodeficiency virus (HIV) infection.

Kirsty Le Doare, Lauren Allen, Beate Kampmann, Paul Trafford Heath, Stephen Taylor, Anneke C Hesseling, Andrew Gorringe, Christine Elizabeth Jones

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  10. Maternal Immunization: Nature Meets Nurture.Frontiers in microbiology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Kirsty Le DoareWellcome Trust/Imperial Centre for Global Health Research/Department of Academic Paediatrics, Imperial College London, Norfolk Place, London W2 1NY, UK; Paediatric Infectious Diseases Research Group, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK. Electronic address: k.mehring-le-doare@imperial.ac.uk.
Lauren AllenPublic Health England, Porton Down, Salisbury SP4 0JG, UK.
Beate KampmannWellcome Trust/Imperial Centre for Global Health Research/Department of Academic Paediatrics, Imperial College London, Norfolk Place, London W2 1NY, UK; Medical Research Council, Atlantic Road, Fajara, Gambia.
Paul Trafford HeathPaediatric Infectious Diseases Research Group, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
Stephen TaylorPublic Health England, Porton Down, Salisbury SP4 0JG, UK.
Anneke C HesselingDesmond Tutu TB Center, Department of Pediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
Andrew GorringePublic Health England, Porton Down, Salisbury SP4 0JG, UK.
Christine Elizabeth JonesWellcome Trust/Imperial Centre for Global Health Research/Department of Academic Paediatrics, Imperial College London, Norfolk Place, London W2 1NY, UK; Paediatric Infectious Diseases Research Group, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK; Desmond Tutu TB Center, Department of Pediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
Public Health England · GBDesmond Tutu HIV Foundation · ZASt George's, University of London · GBMRC Unit the Gambia · GM

Funding

Medical Research Council MC_EX_MR/K011944/1Medical Research Council MC_UP_A900_1122Wellcome Trust KLD2013
6 · The paper itself

Abstract

backgroundHIV-exposed uninfected infants have increased infection risk and mortality compared to HIV-unexposed infants. HIV-exposed infants may be at increased risk of invasive GBS disease due to reduced maternal antibody against GBS.

methodsWe quantified antibodies that bind to the surface of whole Group B Streptococcus (GBS) of serotypes Ia, Ib, II, III and V using novel flow cytometry assays in South African HIV-infected and non-infected mothers and their uninfected infants. Antibody-mediated complement C3b/iC3b deposition onto GBS of these serotypes was also quantified by a novel flow cytometry assay.

resultsGeometric mean concentration (GMC) of both surface-binding anti-GBS antibody and antibody-mediated complement deposition onto GBS were reduced in HIV-infected women (n=46) compared to HIV-uninfected women (n=58) for ST1a (surface-binding: 19.3 vs 29.3; p=0.003; complement deposition: 2.9 vs 5.3 SU/mL; p=0.003), STIb (24.9 vs 47.6; p=0.003; 2.6 vs 4.9 SU/mL; p=0.003), STII (19.8 vs 50.0; p=0.001; 3.1 vs 6.2 SU/mL; p=0.001), STIII (27.8 vs 60.1; p=0.001; 2.8 vs 5.3 SU/mL; p=0.001) and STV (121.9 vs 185.6 SU/mL; p<0.001) and in their infants for STIa (complement deposition 9.4 vs 27.0 SU/mL; p=0.02), STIb (13.4 vs 24.5 SU/mL; p=0.02), STII (14.6 vs 42.7 SU/mL; p=0.03), STIII (26.6 vs 62.7 SU/mL; p=0.03) and STV (90.4 vs 165.8 SU/mL; p=0.04). Median transplacental transfer of antibody from HIV-infected women to their infants was reduced compared to HIV-uninfected women for GBS serotypes II (0.42 [IQR 0.22-0.59] vs 1.0 SU/mL [0.42-1.66]; p<0.001), III (0.54 [0.31-1.03] vs 0.95 SU/mL [0.42-3.05], p=0.05) and V (0.51 [0.28-0.79] vs 0.75 SU/mL [0.26-2.9], p=0.04). The differences between infants remained significant at 16 weeks of age.

conclusionsMaternal HIV infection was associated with lower anti-GBS surface binding antibody concentration and antibody-mediated C3b/iC3b deposition onto GBS bacteria of serotypes Ia, Ib, II, III and V. This may render these infants more susceptible to early and late onset GBS disease.

Indexed as

Immunity, Maternally-AcquiredAntibodies, BacterialCohort StudiesComplement System ProteinsFemaleFlow CytometryHIV InfectionsHumansInfantInfant, NewbornMalePregnancyPregnancy Complications, InfectiousSouth AfricaStreptococcus agalactiaeAntibodies, BacterialComplement System ProteinsAntibodyGroup B StreptococcusHIVHIV-exposed-uninfected infantsImmunity

Identifiers

PMID25543061
PMCPMC4315133
OpenAlexW2014689832

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.