Evidence map›Paper›PMID 25542988›Full record

ArticleInternational journal of pharmaceutics2015

Formulation and characterization of inhalable magnetic nanocomposite microparticles (MnMs) for targeted pulmonary delivery via spray drying.

Nathanael A Stocke, Samantha A Meenach, Susanne M Arnold, Heidi M Mansour, J Zach Hilt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Article
  3. Inhaled Nanoparticulate Systems: Composition, Manufacture and Aerosol Delivery.Journal of aerosol medicine and pulmonary drug delivery · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Repurpose but also (nano)-reformulate! The potential role of nanomedicine in the battle against SARS-CoV2.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Review
  14. Current role of nanoparticles in the treatment of lung cancer.Journal of clinical and translational research · 2021
    Review
  15. Article
  16. Article
  17. Magnetic particle targeting for diagnosis and therapy of lung cancers.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nathanael A StockeCollege of Engineering, Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA.
Samantha A MeenachCollege of Engineering, Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA; College of Pharmacy, Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40506, USA.
Susanne M ArnoldCollege of Medicine, Department of Internal Medicine, University of Kentucky, Lexington, KY 40506, USA.
Heidi M MansourCollege of Pharmacy, Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40506, USA. Electronic address: mansour@pharmacy.arizona.edu.
J Zach HiltCollege of Engineering, Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA. Electronic address: zach.hilt@uky.edu.

Funding

The University of Kentucky Cancer Nanotechnology Training Center (UK CNTC)R25CA153954 · NCI · UNIVERSITY OF KENTUCKY · PI ANDERSON, BRADLEY D, EVERS, BERNARD MARK · 2010 to 2014
$1.6M
NCI NIH HHS R25 CA153954NCI NIH HHS R25CA153954
6 · The paper itself

Abstract

Targeted pulmonary delivery facilitates the direct application of bioactive materials to the lungs in a controlled manner and provides an exciting platform for targeting magnetic nanoparticles (MNPs) to the lungs. Iron oxide MNPs remotely heat in the presence of an alternating magnetic field (AMF) providing unique opportunities for therapeutic applications such as hyperthermia. In this study, spray drying was used to formulate magnetic nanocomposite microparticles (MnMs) consisting of iron oxide MNPs and d-mannitol. The physicochemical properties of these MnMs were evaluated and the in vitro aerosol dispersion performance of the dry powders was measured by the Next Generation Impactor(®). For all powders, the mass median aerosol diameter (MMAD) was <5μm and deposition patterns revealed that MnMs could deposit throughout the lungs. Heating studies with a custom AMF showed that MNPs retain excellent thermal properties after spray drying into composite dry powders, with specific absorption ratios (SAR)>200W/g, and in vitro studies on a human lung cell line indicated moderate cytotoxicity of these materials. These inhalable composites present a class of materials with many potential applications and pose a promising approach for thermal treatment of the lungs through targeted pulmonary administration of MNPs.

Indexed as

Drug Delivery SystemsMagnetite NanoparticlesAerosolsCell LineChemistry, PharmaceuticalDrug CarriersDrug CompoundingHumansLungMagnetic FieldsMannitolNanocompositesParticle SizePowdersAerosolsDrug CarriersMagnetite NanoparticlesMannitolPowdersDry powder inhalation aerosolsIron oxideMagnetic nanoparticlesNanocompositesRemote heatingSpray drying

Identifiers

PMID25542988
PMCPMC5818718

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.