ArticlePhysiology & behavior2015
Using the context preexposure facilitation effect to study long-term context memory in preweanling, juvenile, adolescent, and adult rats.
Article in Physiology & behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Adolescent male and female rats show enhanced latent inhibition of conditioned fear compared to adult rats.Frontiers in behavioral neuroscience · 2025Article
- Retrieval and savings of contextual fear memories across an extended retention interval in juvenile and adult male and female rats.Behavioral neuroscience · 2023Article
- Amygdala circuit transitions supporting developmentally-appropriate social behavior.Neurobiology of learning and memory · 2023Review
- Differential Recruitment of the Infralimbic Cortex in Recent and Remote Retrieval and Extinction of Aversive Memory in Post-Weanling Rats.The international journal of neuropsychopharmacology · 2022Article
- Hippocampal neurogenesis mediates sex-specific effects of social isolation and exercise on fear extinction in adolescence.Neurobiology of stress · 2021Article
- Neurobiology of Infant Fear and Anxiety: Impacts of Delayed Amygdala Development and Attachment Figure Quality.Biological psychiatry · 2021Review
- Excitatory VTA to DH projections provide a valence signal to memory circuits.Nature communications · 2020Article
- Using a Developmental Ecology Framework to Align Fear Neurobiology Across Species.Annual review of clinical psychology · 2019Review
- The ontogeny of memory persistence and specificity.Developmental cognitive neuroscience · 2019Review
- Development of Threat Expression Following Infant Maltreatment: Infant and Adult Enhancement but Adolescent Attenuation.Frontiers in behavioral neuroscience · 2019Article
- Developmental transitions in amygdala PKC isoforms and AMPA receptor expression associated with threat memory in infant rats.Scientific reports · 2018Article
- Sexual differentiation of contextual fear responses.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Impaired contextual fear-conditioning in MAM rodent model of schizophrenia.Schizophrenia research · 2018Article
- Age and experience dependent changes in Egr-1 expression during the ontogeny of the context preexposure facilitation effect (CPFE).Neurobiology of learning and memory · 2018Article
- Antagonism of muscarinic acetylcholine receptors in medial prefrontal cortex disrupts the context preexposure facilitation effect.Neurobiology of learning and memory · 2017Article
- Emotional learning, stress, and development: An ever-changing landscape shaped by early-life experience.Neurobiology of learning and memory · 2017Review
- Adolescent transitions in reflexive and non-reflexive behavior: Review of fear conditioning and impulse control in rodent models.Neuroscience and biobehavioral reviews · 2016Review
- Infantile amnesia reflects a developmental critical period for hippocampal learning.Nature neuroscience · 2016Article
- Adolescent mice are less sensitive to the effects of acute nicotine on context pre-exposure than adults.Brain research · 2016Article
- NMDA receptor antagonism disrupts acquisition and retention of the context preexposure facilitation effect in adolescent rats.Behavioural brain research · 2016Article
Corrections and comments
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2 authors.
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Abstract
The present study used the context preexposure facilitation effect (CPFE) to examine long-term retention of incidental context learning in periweanling, adolescent and adult rats. The CPFE is a variant of contextual fear conditioning in which encoding the context representation, associating this representation with shock, and expressing the context-shock association each occur on separate occasions. Experiment 1 manipulated the retention interval-1d, 8d, 15d, or 22d-between context preexposure and training with immediate shock to determine how long the encoded context could be remembered (testing always occurred 24h following training). The other factors were age-postnatal day (PND) 24 vs 31-and training group-Preexposed to the training context (Pre) vs. an alternate context (Alt-Pre). At both ages, significantly more freezing was evident in the Pre vs. Alt Pre Groups at the 24h, 8d and 15d retention intervals but not at the 22d interval, indicating that juvenile-adolescent rats remember the context for up to 15d. In contrast, context memory persists for 22days in adult rats (Experiment 2); and is not evident after 24h, 8d, or 15d retention intervals in PND 17 rats (Experiment 3). The present study illustrates the value of the CPFE paradigm for investigations of long-term context memory in developing rats. Implications for the neurobiology of infantile amnesia are discussed.
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