Evidence map›Paper›PMID 25542797›Full record

ArticleBiomaterials2015

Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide.

Xuefeng Yan, Gang Niu, Jing Lin, Albert J Jin, Hao Hu, Yuxia Tang, Yujie Zhang, Aiguo Wu, Jie Lu, Shaoliang Zhang and 3 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 157 citations in OpenAlex.

  1. Review
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  8. Carbon Nanomaterials: Emerging Roles in Immuno-Oncology.International journal of molecular sciences · 2023
    Review
  9. Article
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  11. Graphene-Based Nanomaterials for Biomedical Imaging.Advances in experimental medicine and biology · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Xuefeng YanDepartment of Radiology, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China; National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 Center Drive, Bethesda, MD 20892, United States; Molecular Imaging Center of Harbin Medical University, Harbin, Heilongjiang, China.
Gang NiuNational Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 Center Drive, Bethesda, MD 20892, United States.
Jing LinNational Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 Center Drive, Bethesda, MD 20892, United States.
Albert J JinLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD 20892, United States.
Hao HuNational Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 Center Drive, Bethesda, MD 20892, United States.
Yuxia TangNational Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 Center Drive, Bethesda, MD 20892, United States.
Yujie ZhangKey Laboratory of Magnetic Materials and Devices, & Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang 315201, China.
Aiguo WuKey Laboratory of Magnetic Materials and Devices, & Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang 315201, China.
Jie LuNational Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 Center Drive, Bethesda, MD 20892, United States.
Shaoliang ZhangJiangxi Qinglong Group Co., Ltd., No. 283 Dongfeng Street, Yichun, Jiangxi 336000, China.
Peng HuangNational Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 Center Drive, Bethesda, MD 20892, United States. Electronic address: peng.huang@nih.gov.
Baozhong ShenDepartment of Radiology, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China; Molecular Imaging Center of Harbin Medical University, Harbin, Heilongjiang, China. Electronic address: shenbzh@vip.sina.com.
Xiaoyuan ChenNational Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 Center Drive, Bethesda, MD 20892, United States. Electronic address: shawn.chen@nih.gov.
National Institutes of Health · USNational Institute of Biomedical Imaging and Bioengineering · USChinese Academy of Sciences · CNFourth Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CNNingbo Institute of Industrial Technology · CN

Funding

Laboratory of Molecular Imaging and NanomedicineZIAEB000073 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI CHEN, XIAOYUAN · 2010 to 2020
$32.8M
Biomedical Studies and Cellular Imaging via Atomic Force MicroscopyZIAEB000015 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI JIN, ALBERT J · 2009 to 2025
$5.8M
Intramural NIH HHS Z99 EB999999
6 · The paper itself

Abstract

Extensive research indicates that graphene oxide (GO) can effectively deliver photosensitives (PSs) by π-π stacking for photodynamic therapy (PDT). However, due to the tight complexes of GO and PSs, the fluorescence of PSs are often drastically quenched via an energy/charge transfer process, which limits GO-PS systems for photodiagnostics especially in fluorescence imaging. To solve this problem, we herein strategically designed and prepared a novel photo-theranostic agent based on sinoporphyrin sodium (DVDMS) loaded PEGylated GO (GO-PEG-DVDMS) with improved fluorescence property for enhanced optical imaging guided PDT. The fluorescence of loaded DVDMS is drastically enhanced via intramolecular charge transfer. Meanwhile, the GO-PEG vehicles can significantly increase the tumor accumulation efficiency of DVDMS and lead to an improved PDT efficacy as compared to DVDMS alone. The cancer theranostic capability of the as-prepared GO-PEG-DVDMS was carefully investigated both in vitro and in vivo. Most intriguingly, 100% in vivo tumor elimination was achieved by intravenous injection of GO-PEG-DVDMS (2 mg/kg of DVDMS, 50 J) without tumor recurrence, loss of body weight or other noticeable toxicity. This novel GO-PEG-DVDMS theranostics is well suited for enhanced fluorescence imaging guided PDT.

Indexed as

Diagnostic ImagingPhotochemotherapyAnimalsCell DeathCell Line, TumorCell SurvivalEndocytosisFlow CytometryGraphiteHumansIntracellular SpaceMice, NudeMicroscopy, Atomic ForceOxidesPolyethylene GlycolsPorphyrinsGraphiteOxidesPolyethylene GlycolsPorphyrinsSinglet Oxygensinoporphyrin sodiumFluorescence imagingGraphene oxide (GO)Photodynamic therapyPhotosensitizerSinoporphyrin sodium (DVDMS)

Identifiers

PMID25542797
PMCPMC4280503
OpenAlexW2081411459

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.