ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2015
Poststroke fatigue: hints to a biological mechanism.
Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Neuroimaging correlates of post-stroke fatigue: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- Genetic variants at theRMD open · 2021Pooled it
- A systematic review of the association between fatigue and genetic polymorphisms.Brain, behavior, and immunity · 2017Pooled it
- Modafinil treatment modulates functional connectivity in stroke survivors with severe fatigue.Scientific reports · 2019Trial
- Post-stroke fatigue as an indicator of underlying bioenergetics alterations.Journal of bioenergetics and biomembranes · 2019Trial
- Article
- Fatigue, Toll-Like Receptor 4, and Pro-Inflammatory Cytokines in Adults With Subarachnoid Hemorrhage: A 6-Month Longitudinal Study.Biological research for nursing · 2024Review
- A roadmap for research in post-stroke fatigue: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable.International journal of stroke : official journal of the International Stroke Society · 2024Article
- A roadmap for research in post-stroke fatigue: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable.Neurorehabilitation and neural repair · 2024Article
- Mechanisms of Post-Stroke Fatigue: A Follow-Up From the Third Stroke Recovery and Rehabilitation Roundtable.Neurorehabilitation and neural repair · 2024Review
- Drivers of Chronic Pathology Following Ischemic Stroke: A Descriptive Review.Cellular and molecular neurobiology · 2023Review
- Post-stroke fatigue: a review of development, prevalence, predisposing factors, measurements, and treatments.Frontiers in neurology · 2023Review
- Neural effective connectivity explains subjective fatigue in stroke.Brain : a journal of neurology · 2022Observational
- Fatigue after acquired brain injury impacts health-related quality of life: an exploratory cohort study.Scientific reports · 2021Article
- Aneurysmal subarachnoid haemorrhage: effect of CRHR1 genotype on fatigue and depression.BMC neurology · 2020Article
- Role of TLR4 (C1196T) and CD14 (C-260T) Polymorphisms in Development of Ischemic Stroke, Its Subtypes and Hemorrhagic Stroke.Journal of molecular neuroscience : MN · 2017Article
- Interleukin-1 as a mediator of fatigue in disease: a narrative review.Journal of neuroinflammation · 2017Review
- No structural cerebral MRI changes related to fatigue in patients with primary Sjögren's syndrome.Rheumatology advances in practice · 2017Article
- Inflammation and the Silent Sequelae of Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Exploratory Cohort Study of Associations between Serum C - Reactive Protein and Fatigue after Stroke.PloS one · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPoststroke fatigue (PSF) is common, but the biological basis of this fatigue is unknown. We explored the possibility that PSF is related to systemic inflammation by investigating polymorphisms in 2 genes that affect the immune response.
methodsIn a substudy of a larger trial that evaluated the role of the immune response on stroke outcome, fatigue was assessed at 30, 90, 180, and 365 days after ischemic stroke using the Fatigue Assessment Scale. Subjects were genotyped for 3 single nucleotide polymorphisms, one in the interleukin-1 receptor antagonist gene (IL1RN; rs4251961, a T/C substitution) and two in the in toll-like receptor-4 (TLR4) gene (1063 A/G [Asp299Gly] rs4986790 and 1363 C/T [Thr399Ile] rs4986791).
resultsOf the 39 participants, 22 (56%) endorsed fatigue during the study. The degree of fatigue was remarkably constant over time and independent of stroke outcome. The C allele of the rs4251961 single nucleotide polymorphism (SNP) in IL1RN was associated with self-reported fatigue (P = .03), whereas the cosegregating polymorphisms in TLR4 were associated with lower levels of fatigue (P= .04).
conclusionsSNPs in 2 genes with opposing effects on inflammatory immune responses were significantly, but differentially, associated with PSF. These findings suggest a direct link between immune signaling dysregulation and PSF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.