ArticleFitoterapia2015
A galloylated dimeric proanthocyanidin from grape seed exhibits dentin biomodification potential.
Article in Fitoterapia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Identification and Structural Elucidation of Galloylated B-Type Procyanidins From Rumex obtusifolius L. Using Enzymatic Digestion, Phloroglucinolysis, and High-Resolution Mass Spectrometry.Journal of separation science · 2026Article
- A dual action approach of B-type proanthocyanidins for silencing enzymatic activity and sealing natural caries-affected dentin-resin interfaces.Journal of dentistry · 2025Article
- Article
- Impact of a plant-derived agent on bond strength of self-adhesive resin cement luting of glass-fiber posts.Brazilian dental journal · 2025Article
- Evaluation of the efficacy of various remineralization agents and grape seed extract on microhardness and lesion depth of primary tooth enamel: An in vitro study.Journal of dental research, dental clinics, dental prospects · 2024Article
- Does the pH of the grape seed extract interfere in the biomodification capacity of dentin collagen?Brazilian dental journal · 2024Article
- Development of Proanthocyanidin-Loaded Mesoporous Silica Nanoparticles for Improving Dental Adhesion.Molecular pharmaceutics · 2022Article
- Salivary esterases dramatically reduce biostability of dentin collagen treated with galloylated polyphenols.Dental materials : official publication of the Academy of Dental Materials · 2022Article
- Galloylated proanthocyanidins in dentin matrix exhibit biocompatibility and induce differentiation in dental stem cells.Journal of bioactive and compatible polymers · 2022Article
- Collagen Cross-Linking Lignin Improves the Bonding Performance of Etch-and-Rinse Adhesives to Dentin.Materials (Basel, Switzerland) · 2022Article
- Exploitation ofMolecules (Basel, Switzerland) · 2021Article
- A dynamic mechanical method to assess bulk viscoelastic behavior of the dentin extracellular matrix.Dental materials : official publication of the Academy of Dental Materials · 2020Article
- Effect of dentin biomodification delivered by experimental acidic and neutral primers on resin adhesion.Journal of dentistry · 2020Article
- Polyphenols in Dental Applications.Bioengineering (Basel, Switzerland) · 2020Review
- Effect of tea root-derived proanthocyanidin fractions on protection of dentin collagen.The Journal of international medical research · 2020Article
- Classification of Flavonoid Metabolomes via Data Mining and Quantification of Hydroxyl NMR Signals.Analytical chemistry · 2020Article
- Dimeric Proanthocyanidins on the Stability of Dentin and Adhesive Biointerfaces.Journal of dental research · 2020Article
- Proanthocyanidin Dimers and Trimers fromJournal of natural products · 2019Article
- Evidence to the role of interflavan linkages and galloylation of proanthocyanidins at sustaining long-term dentin biomodification.Dental materials : official publication of the Academy of Dental Materials · 2019Article
- Centrifugal partition chromatography enables selective enrichment of trimeric and tetrameric proanthocyanidins for biomaterial development.Journal of chromatography. A · 2018Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Grape seeds are a rich source of polyphenols, especially proanthocyanidins (PACs), and are also known for the presence of galloylated oligomeric PACs (OPACs). The present study focuses on the phytochemical methodology for grape seed (O)PACs and their potential role as dentin biomodifiers to be used in restorative and reparative dentistry. A new method using centrifugal partition chromatography (CPC) was developed for the preparative separation of the grape seed (O)PACs. Orthogonal phytochemical profiling of the resulting CPC fractions was performed using C18 and diol HPLC, normal phase HPTLC, and IT-TOF MS analysis. A galloylated procyanidin dimer (1) was isolated from a CPC fraction in order to evaluate its potential to enhance dentin bio-mechanical properties. Moreover, it helped to evaluate the impact of the galloyl moiety on the observed bioactivity. Structure elucidation was performed using ESI-MS, 1D and 2D NMR analyses. For the first time, (1)H iterative full spin analysis (HiFSA) was performed on this type of molecule, enabling a detailed proton chemical shift and coupling constant assignment. The CPC fractions as well as 1 showed promising results in the dentin stiffness bioassay and indicate that they may be used as dental intervention biomaterial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.