Evidence map›Paper›PMID 25542591›Full record

ReviewJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia2015

Epileptogenic focus localization in treatment-resistant post-traumatic epilepsy.

Andrei Irimia, John Darrell Van Horn

Abstract readReview
In one paragraph

Review in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Investigation of the effectiveness of vagus nerve stimulation for pediatric drug-resistant epilepsies secondary to nonaccidental trauma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
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  12. Review
  13. Article
  14. Review
  15. Article
  16. Neuroimaging of traumatic brain injury in military personnel: An overview.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2019
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrei IrimiaThe Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, 2001 North Soto Street, SSB1-102, Los Angeles, CA 90032, USA.
John Darrell Van HornThe Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, 2001 North Soto Street, SSB1-102, Los Angeles, CA 90032, USA. Electronic address: jvanhorn@usc.edu.

Funding

Washington University ConsoritumU54EB005149 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON · 2004 to 2013
$39.3M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Multimodality image-based assessment system for traumatic brain injuryR41NS081792 · NINDS · KITWARE, INC. · PI AYLWARD, STEPHEN R · 2013 to 2014
$297k
NIBIB NIH HHS 2U54EB005149-06NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB005149NINDS NIH HHS R41 NS081792NINDS NIH HHS R41NS081792-01
6 · The paper itself

Abstract

Pharmacologically intractable post-traumatic epilepsy (PTE) is a major clinical challenge for patients with penetrating traumatic brain injury, where the risk for this condition remains very high even decades after injury. Although over 20 anti-epileptic drugs (AED) are in common use today, approximately one-third of epilepsy patients have drug-refractory seizures and even more have AED-related adverse effects which compromise life quality. Simultaneously, there have been repeated recommendations by radiologists and neuroimaging experts to incorporate localization based on electroencephalography (EEG) into the process of clinical decision making regarding PTE patients. Nevertheless, thus far, little progress has been accomplished towards the use of EEG as a reliable tool for locating epileptogenic foci prior to surgical resection. In this review, we discuss the epidemiology of pharmacologically resistant PTE, address the need for effective anti-epileptogenic treatments, and highlight recent progress in the development of noninvasive methods for the accurate localization of PTE foci for the purpose of neurosurgical intervention. These trends indicate the current emergence of promising methodologies for the noninvasive study of post-traumatic epileptogenesis and for the improved neurosurgical planning of epileptic foci resection.

Indexed as

AnticonvulsantsDrug Resistant EpilepsyElectroencephalographyEpilepsy, Post-TraumaticHumansNeurosurgical ProceduresAnticonvulsantsElectroencephalographyEpileptogenesisInverse localizationPharmacological resistancePost-traumatic epilepsyTraumatic brain injury

Identifiers

PMID25542591
PMCPMC4380645

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.