ArticleBMC genomics2014
Analysis of the basal chordate Botryllus schlosseri reveals a set of genes associated with fertility.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- First chromosome-level genome assembly of the colonial chordate model Botryllus schlosseri (Tunicata).GigaScience · 2025Article
- Genotype-specific Expression of Uncle Fester Suggests a Role in Allorecognition Education in a Basal Chordate.Integrative and comparative biology · 2024Article
- Genotype-specific expression ofbioRxiv : the preprint server for biology · 2024Article
- Increased collective migration correlates with germline stem cell competition in a basal chordate.PloS one · 2023Article
- Metazoans and Intrinsic Apoptosis: An Evolutionary Analysis of the Bcl-2 Family.International journal of molecular sciences · 2022Article
- Vascular Aging in the Invertebrate Chordate,Frontiers in molecular biosciences · 2021Article
- Evidence that ABC transporter-mediated autocrine export of an eicosanoid signaling molecule enhances germ cell chemotaxis in the colonial tunicateDevelopment (Cambridge, England) · 2020Article
- Shotgun Proteomics of Ascidians Tunic Gives New Insights on Host-Microbe Interactions by Revealing Diverse Antimicrobial Peptides.Marine drugs · 2020Article
- Article
- Convergent Acquisition of Nonembryonic Development in Styelid Ascidians.Molecular biology and evolution · 2018Article
- In vivo manipulation of the extracellular matrix induces vascular regression in a basal chordate.Molecular biology of the cell · 2017Article
- Identification of differentially expressed genes from multipotent epithelia at the onset of an asexual development.Scientific reports · 2016Article
- Transcriptome dynamics in the asexual cycle of the chordate Botryllus schlosseri.BMC genomics · 2016Article
- Article
- Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate.Nature communications · 2015Article
- Molecular evolution and in vitro characterization of Botryllus histocompatibility factor.Immunogenetics · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundGonad differentiation is an essential function for all sexually reproducing species, and many aspects of these developmental processes are highly conserved among the metazoa. The colonial ascidian, Botryllus schlosseri is a chordate model organism which offers two unique traits that can be utilized to characterize the genes underlying germline development: a colonial life history and variable fertility. These properties allow individual genotypes to be isolated at different stages of fertility and gene expression can be characterized comprehensively.
resultsHere we characterized the transcriptome of both fertile and infertile colonies throughout blastogenesis (asexual development) using differential expression analysis. We identified genes (as few as 7 and as many as 647) regulating fertility in Botryllus at each stage of blastogenesis. Several of these genes appear to drive gonad maturation, as they are expressed by follicle cells surrounding both testis and oocyte precursors. Spatial and temporal expression of differentially expressed genes was analyzed by in situ hybridization, confirming expression in developing gonads.
conclusionWe have identified several genes expressed in developing and mature gonads in B. schlosseri. Analysis of genes upregulated in fertile animals suggests a high level of conservation of the mechanisms regulating fertility between basal chordates and vertebrates.
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