ArticleFree radical biology & medicine2015
Ochratoxin A promotes porcine circovirus type 2 replication in vitro and in vivo.
Article in Free radical biology & medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
- Matrine regulates autophagy in ileal epithelial cells in a porcine circovirus type 2-infected murine model.Frontiers in microbiology · 2024Article
- Mycotoxins in Cereal-Based Products and Their Impacts on the Health of Humans, Livestock Animals and Pets.Toxins · 2023Review
- Immunotoxicity of Three Environmental Mycotoxins and Their Risks of Increasing Pathogen Infections.Toxins · 2023Review
- Enzymatic degradation of ochratoxin A in the gastrointestinal tract of piglets.Journal of animal science · 2023Article
- Inhalation toxicity of mycotoxins in farm animals.Iranian journal of veterinary research · 2023Article
- Low-Concentration T-2 Toxin Attenuates Pseudorabies Virus Replication in Porcine Kidney 15 Cells.Toxins · 2022Article
- Protective and detoxifying effects conferred by selenium against mycotoxins and livestock viruses: A review.Frontiers in veterinary science · 2022Review
- Mold, Mycotoxins and a Dysregulated Immune System: A Combination of Concern?International journal of molecular sciences · 2021Review
- PK15 cell line stably overexpressing IL2 enhances PCV2 replication.Virus genes · 2021Article
- Interactions between Autophagy and DNA Viruses.Viruses · 2019Review
- PCV2 replication promoted by oxidative stress is dependent on the regulation of autophagy on apoptosis.Veterinary research · 2019Article
- Increased fucoxanthin inBiotechnology reports (Amsterdam, Netherlands) · 2019Article
- Protective effects of zymosan on heat stress-induced immunosuppression and apoptosis in dairy cows and peripheral blood mononuclear cells.Cell stress & chaperones · 2018Article
- SeMet attenuates OTA-induced PCV2 replication promotion by inhibiting autophagy by activating the AKT/mTOR signaling pathway.Veterinary research · 2018Article
- Aflatoxin BFrontiers in immunology · 2018Article
- Ochratoxin A-induced autophagy in vitro and in vivo promotes porcine circovirus type 2 replication.Cell death & disease · 2017Article
- Astragalus polysaccharides attenuate PCV2 infection by inhibiting endoplasmic reticulum stress in vivo and in vitro.Scientific reports · 2017Article
- T Cell Activation in South African HIV-Exposed Infants Correlates with Ochratoxin A Exposure.Frontiers in immunology · 2017Article
- Interactions of porcine circovirus 2 with its hosts.Virus genes · 2016Review
- Impact of mycotoxin on immune response and consequences for pig health.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ochratoxin A (OTA), a worldwide mycotoxin found in food and feeds, is a potent nephrotoxin in animals and humans. Porcine circovirus-associated disease (PCVAD), including porcine dermatitis and nephropathy syndrome, is a worldwide swine disease. To date, little is known concerning the relationship between OTA and porcine circovirus type 2 (PCV2), the primary causative agent of PCVAD. The effects of OTA on PCV2 replication and their mechanisms were investigated in vitro and in vivo. The results in vitro showed that low doses of OTA significantly increased PCV2 DNA copies and the number of infected cells. Maximum effects were observed at 0.05 μg/ml OTA. The results in vivo showed that PCV2 replication was significantly increased in serum and tissues of pigs fed 75 μg/kg OTA compared with the control group and pigs fed 150 μg/kg OTA. In addition, low doses of OTA significantly depleted reduced glutathione and mRNA expression of NF-E2-related factor 2 and γ-glutamylcysteine synthetase; increased reactive oxygen species, oxidants, and malondialdehyde; and induced p38 and ERK1/2 phosphorylation in PK15 cells. Adding N-acetyl-L-cysteine reversed the changes induced by OTA. Knockdown of p38 and ERK1/2 by their respective specific siRNAs or inhibition of p38 and ERK1/2 phosphorylation by their respective inhibitors (SB203580 and U0126) eliminated the increase in PCV2 replication induced by OTA. These data indicate that low doses of OTA promoted PCV2 replication in vitro and in vivo via the oxidative stress-mediated p38/ERK1/2 MAPK signaling pathway. This suggests that low doses of OTA are potentially harmful to animals, as they enhance virus replication, and partly explains why the morbidity and severity of PCVAD vary significantly in different pig farms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.