ArticlePloS one2014
Exhaled breath analysis using electronic nose in cystic fibrosis and primary ciliary dyskinesia patients with chronic pulmonary infections.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Volatile Organic Compounds in Human Exhaled Breath to Diagnose Gastrointestinal Cancer: A Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Metal-organic frameworks for breath-based sensors: a review.Mikrochimica acta · 2026Review
- Review
- The Non-Invasive Detection of Pulmonary Exacerbations in Disorders of Mucociliary Clearance with Breath Analysis: A Systematic Review.Journal of clinical medicine · 2024Review
- Exhaled Breath Analysis Detects the Clearance ofBiomedicines · 2024Article
- Detection of Bacterial Colonization in Lung Transplant Recipients Using an Electronic Nose.Transplantation direct · 2023Article
- Exhaled Biomarkers for Point-of-Care Diagnosis: Recent Advances and New Challenges in Breathomics.Micromachines · 2023Review
- Selective and self-validating breath-level detection of hydrogen sulfide in humid air by gold nanoparticle-functionalized nanotube arrays.Nano research · 2022Article
- Lower airway clinical outcome measures for use in primary ciliary dyskinesia research: a scoping review.ERJ open research · 2021Article
- The smell of lung disease: a review of the current status of electronic nose technology.Respiratory research · 2021Review
- Proof of concept for real-time detection of SARS CoV-2 infection with an electronic nose.PloS one · 2021Article
- Potential of the Electronic Nose for the Detection of Respiratory Diseases with and without Infection.International journal of molecular sciences · 2020Review
- Motile ciliopathies.Nature reviews. Disease primers · 2020Review
- Influence of media on the differentiation of Staphylococcus spp. by volatile compounds.Journal of breath research · 2019Article
- Sensors for detecting pulmonary diseases from exhaled breath.European respiratory review : an official journal of the European Respiratory Society · 2019Review
- [Biologics in Rhinology - Forthcoming Personalized Concepts: the Future Starts Today].Laryngo- rhino- otologie · 2018Review
- Mapping targetable inflammation and outcomes with cystic fibrosis biomarkers.Pediatric pulmonology · 2017Review
- Lung structure and function similarities between primary ciliary dyskinesia and mild cystic fibrosis: a pilot study.Italian journal of pediatrics · 2017Article
- Review
- CFTR Modulator Therapies in Pediatric Cystic Fibrosis: Focus on Ivacaftor.Expert opinion on orphan drugs · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current diagnostic work-up and monitoring of pulmonary infections may be perceived as invasive, is time consuming and expensive. In this explorative study, we investigated whether or not a non-invasive exhaled breath analysis using an electronic nose would discriminate between cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) with or without various well characterized chronic pulmonary infections. We recruited 64 patients with CF and 21 with PCD based on known chronic infection status. 21 healthy volunteers served as controls. An electronic nose was employed to analyze exhaled breath samples. Principal component reduction and discriminant analysis were used to construct internally cross-validated receiver operator characteristic (ROC) curves. Breath profiles of CF and PCD patients differed significantly from healthy controls p = 0.001 and p = 0.005, respectively. Profiles of CF patients having a chronic P. aeruginosa infection differed significantly from to non-chronically infected CF patients p = 0.044. We confirmed the previously established discriminative power of exhaled breath analysis in separation between healthy subjects and patients with CF or PCD. Furthermore, this method significantly discriminates CF patients suffering from a chronic pulmonary P. aeruginosa (PA) infection from CF patients without a chronic pulmonary infection. Further studies are needed for verification and to investigate the role of electronic nose technology in the very early diagnostic workup of pulmonary infections before the establishment of a chronic infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.