SynthesisPloS one2014
Prospective associations of coronary heart disease loci in African Americans using the MetaboChip: the PAGE study.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.Nature genetics · 2017Pooled it
- Genetic Risk Stratification: A Paradigm Shift in Prevention of Coronary Artery Disease.JACC. Basic to translational science · 2021Review
- Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups.American journal of human genetics · 2020Article
- Association of CMYC polymorphisms with hepatoblastoma risk.Translational cancer research · 2020Article
- Genome-Wide Association Studies of Coronary Artery Disease: Recent Progress and Challenges Ahead.Current atherosclerosis reports · 2018Review
- Weighted Multi-marker Genetic Risk Scores for Incident Coronary Heart Disease among Individuals of African, Latino and East-Asian Ancestry.Scientific reports · 2018Article
- A genetic association study of carotid intima-media thickness (CIMT) and plaque in Mexican Americans and European Americans with rheumatoid arthritis.Atherosclerosis · 2018Article
- Data on genetic associations of carotid atherosclerosis markers in Mexican American and European American rheumatoid arthritis subjects.Data in brief · 2018Article
- Evaluation of 71 Coronary Artery Disease Risk Variants in a Multiethnic Cohort.Frontiers in cardiovascular medicine · 2018Article
- Article
- Genetics of stroke in a UK African ancestry case-control study: South London Ethnicity and Stroke Study.Neurology. Genetics · 2017Article
- Association between genetic loci linked to HDL-C levels and Indian patients with CAD: a pilot study.Heart Asia · 2017Article
- Influence of Genetic Risk Factors on Coronary Heart Disease Occurrence in Afro-Caribbeans.The Canadian journal of cardiology · 2016Article
Corrections and comments
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Authors and funding
31 authors.
Funding
Abstract
backgroundCoronary heart disease (CHD) is a leading cause of morbidity and mortality in African Americans. However, there is a paucity of studies assessing genetic determinants of CHD in African Americans. We examined the association of published variants in CHD loci with incident CHD, attempted to fine map these loci, and characterize novel variants influencing CHD risk in African Americans. METHODS AND
resultsUp to 8,201 African Americans (including 546 first CHD events) were genotyped using the MetaboChip array in the Atherosclerosis Risk in Communities (ARIC) study and Women's Health Initiative (WHI). We tested associations using Cox proportional hazard models in sex- and study-stratified analyses and combined results using meta-analysis. Among 44 validated CHD loci available in the array, we replicated and fine-mapped the SORT1 locus, and showed same direction of effects as reported in studies of individuals of European ancestry for SNPs in 22 additional published loci. We also identified a SNP achieving array wide significance (MYC: rs2070583, allele frequency 0.02, P = 8.1 × 10(-8)), but the association did not replicate in an additional 8,059 African Americans (577 events) from the WHI, HealthABC and GeneSTAR studies, and in a meta-analysis of 5 cohort studies of European ancestry (24,024 individuals including 1,570 cases of MI and 2,406 cases of CHD) from the CHARGE Consortium.
conclusionsOur findings suggest that some CHD loci previously identified in individuals of European ancestry may be relevant to incident CHD in African Americans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.