Evidence map›Paper›PMID 25541707›Full record

ArticlePloS one2014

Antiretroviral treatment program retention among HIV-infected children in the Democratic Republic of Congo.

John Ditekemena, Christophe Luhata, William Bonane, Modeste Kiumbu, Antoinette Tshefu, Robert Colebunders, Olivier Koole

Abstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

John DitekemenaElizabeth Glaser Paediatric AIDS Foundation, Kinshasa, Democratic Republic of Congo.
Christophe LuhataKinshasa School of Public Health, Kinshasa, Democratic Republic of Congo.
William BonaneHeal Africa, Goma, Democratic Republic of Congo.
Modeste KiumbuKinshasa School of Public Health, Kinshasa, Democratic Republic of Congo.
Antoinette TshefuKinshasa School of Public Health, Kinshasa, Democratic Republic of Congo.
Robert ColebundersUniversity of Antwerp, Antwerp, Belgium.
Olivier KooleLondon School of Hygiene and Tropical Medicine, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRetaining patients with HIV infection in care is still a major challenge in sub- Saharan Africa, particularly in the Democratic Republic of Congo (DRC) where the antiretroviral treatment (ART) coverage is low. Monitoring retention is an important tool for evaluating the quality of care. METHODS AND

findingsA review of medical records of HIV-infected children was performed in three health facilities in the DRC: the Amo-Congo Health center, the Monkole Clinic in Kinshasa, and the HEAL Africa Clinic in Goma. Medical records of 720 children were included. Kaplan Meier curves were constructed with the probability of retention at 6 months, 1 year, 2 years and 3 years. Retention rates were: 88.2% (95% CI: 85.1%-90.8%) at 6 months; 85% (95% CI: 81.5%-87.6%) at one year; 79.4% (95%CI: 75.5%-82.8%) at two years and 74.7% (95% CI: 70.5%-78.5%) at 3 years. The retention varied across study sites: 88.2%, 66.6% and 92.5% at 6 months; 84%, 59% and 90% at 12 months and 75.7%, 56.3% and 85.8% at 24 months respectively for Amo-Congo/Kasavubu, Monkole facility and HEAL Africa. After multivariable Cox regression four variables remained independently associated with attrition: study site, CD4 cell count <350 cells/µL, children younger than 2 years and children whose caregivers were member of an independent church.

conclusionsAttrition remains a challenge for pediatric HIV positive patients in ART programs in DRC. In addition, the low coverage of pediatric treatment exacerbates the situation of pediatric HIV/AIDS.

Indexed as

Drug MonitoringAdolescentAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveChildChild, PreschoolDatabases, FactualDemocratic Republic of the CongoHealth FacilitiesHIV InfectionsHumansInfantRetrospective StudiesRisk FactorsAnti-Retroviral Agents

Identifiers

PMID25541707
PMCPMC4277274

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.