ArticleACS photonics2014
Diffusion Reflection and Fluorescence Lifetime Imaging Microscopy Study of Fluorophore-Conjugated Gold Nanoparticles or Nanorods in Solid Phantoms.
Article in ACS photonics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Plasmon-enhanced fluorescence for biophotonics and bio-analytical applications.Frontiers in chemistry · 2024Review
- Imaging the rotational mobility of carbon dot-gold nanoparticle conjugates using frequency domain wide-field time-resolved fluorescence anisotropy.Journal of biomedical optics · 2023Article
- Two-photon fluorescence lifetime imaging microscopy of NADH metabolism in HIV-1 infected cells and tissues.Frontiers in immunology · 2023Article
- Characterization of Diabetic Retinopathy in Two Mouse Models and Response to a Single Injection of Anti-Vascular Endothelial Growth Factor.International journal of molecular sciences · 2022Article
- Colon phantoms with cancer lesions for endoscopic characterization with optical coherence tomography.Biomedical optics express · 2021Article
- Porous Phantoms Mimicking Tissues-Investigation of Optical Parameters Stability Over Time.Materials (Basel, Switzerland) · 2021Article
- Gold Rod-Polyethylene Glycol-Carbon Dot Nanohybrids as Phototheranostic Probes.Nanomaterials (Basel, Switzerland) · 2018Article
- Self-Calibration Phenomenon for Near-Infrared Clinical Measurements: Theory, Simulation, and Experiments.ACS omega · 2018Article
- Fluorescence Lifetime Imaging Microscopy, a Novel Diagnostic Tool for Metastatic Cell Detection in the Cerebrospinal Fluid of Children with Medulloblastoma.Scientific reports · 2017Article
- Tissue-Like Phantoms as a Platform for Inserted Fluorescence Nano-Probes.Materials (Basel, Switzerland) · 2016Article
- Nanoparticle-free tissue-mimicking phantoms with intrinsic scattering.Biomedical optics express · 2016Article
- Extremely sensitive dual imaging system in solid phantoms.Proceedings of SPIE--the International Society for Optical Engineering · 2016Article
- An ultra-sensitive dual-mode imaging system using metal-enhanced fluorescence in solid phantoms.Nano research · 2015Article
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Authors and funding
3 authors.
Funding
Abstract
In this paper we report the optical properties of fluorescein-conjugated gold nanoparticles (GNPs) in solid phantoms using diffusion reflection (DR) and fluorescence lifetime imaging microscopy (FLIM). The GNPs attached with fluorescein in solution were studied by fluorescence correlation spectroscopy. The intensity decays were recorded to reveal the fluorescence lifetime of fluorescein while in the near-field vicinity of the GNPs. The DR method was used to explore the solid phantoms containing GNPs, indicating the light propagation from the surface of solid phantoms. The resulting DR slopes of the reflected intensity showed the higher the GNP concentration, the bigger the slope. Fluorescence intensity, lifetime, and anisotropy images of solid phantoms were investigated by FLIM. The exploration of optical properties and molecular imaging combined with DR and FLIM methods is a new approach that has not been established until now. The combined DR-FLIM technique is expected to provide discrimination based on unique spectroscopic fingerprints of GNPs that could be utilized for cell imaging. This paper includes a combined study with a variety of methods, which may lead to multimodal imaging for surfaces (by FLIM) and deep penetration (up to cm by the DR) together.
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