ReviewCurrent opinion in microbiology2015
Bacterial-induced cell reprogramming to stem cell-like cells: new premise in host-pathogen interactions.
Review in Current opinion in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Revisiting Pluripotency Acquisition: A Unified Framework for Reprogramming Strategies.Development, growth & differentiation · 2026Review
- The use of stem cells and organoids for modeling host-microbe interactions in low-biomass tissues.Frontiers in cellular and infection microbiology · 2025Review
- Microbial β-Glucuronidase Hydrogel Beads Activate Chemotherapeutic Prodrug.ACS applied materials & interfaces · 2024Article
- Article
- In vivo partial reprogramming by bacteria promotes adult liver organ growth without fibrosis and tumorigenesis.Cell reports. Medicine · 2022Article
- The protective role of tissue-resident interleukin 17A-producing gamma delta T cells in MycobacteriumFrontiers in immunology · 2022Article
- A new paradigm for leprosy diagnosis based on host gene expression.PLoS pathogens · 2021Article
- Reanalysis and integration of public microarray datasets reveals novel host genes modulated in leprosy.Molecular genetics and genomics : MGG · 2020Article
- Functional Impairment of Skin Appendages Due to Peripheral Nerve Involvement byOpen forum infectious diseases · 2020Article
- From Gene to Protein-How Bacterial Virulence Factors Manipulate Host Gene Expression During Infection.International journal of molecular sciences · 2020Review
- Cell Biology of Intracellular Adaptation ofMicrobiology spectrum · 2019Review
- World leprosy day 2018: How forward respecting the past?The Indian journal of medical research · 2018Article
- A review on host-pathogen interactions: classification and prediction.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Bacterial pathogens employ a myriad of strategies to alter host tissue cell functions for bacterial advantage during infection. Recent advances revealed a fusion of infection biology with stem cell biology by demonstrating developmental reprogramming of lineage committed host glial cells to progenitor/stem cell-like cells by an intracellular bacterial pathogen Mycobacterium leprae. Acquisition of migratory and immunomodulatory properties of such reprogrammed cells provides an added advantage for promoting bacterial spread. This presents a previously unseen sophistication of cell manipulation by hijacking the genomic plasticity of host cells by a human bacterial pathogen. The rationale for such extreme fate conversion of host cells may be directly linked to the exceedingly passive obligate life style of M. leprae with a degraded genome and host cell dependence for both bacterial survival and dissemination, particularly the use of host-derived stem cell-like cells as a vehicle for spreading infection without being detected by immune cells. Thus, this unexpected link between cell reprogramming and infection opens up a new premise in host-pathogen interactions. Furthermore, such bacterial ingenuity could also be harnessed for developing natural ways of reprogramming host cells for repairing damaged tissues from infection, injury and diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.